Results 141 to 150 of about 92,958 (217)

Sequential Homo‐ and Hetero‐Coupling of Isocyanide and Carbon Monoxide Mediated by Acyclic Imino(silyl)Silylene

Angewandte Chemie, EarlyView.
We demonstrate the sequential reactions between an imino(hypersilyl)silylene and aryl isocyanide or carbon monoxide as a molecular‐level model of the Fischer–Tropsch process, providing systematic and detailed insight into C–C bond formation during the homologation of C1 building blocks.
Huaiyuan Zhu, Arseni Kostenko, Xufang Liu, Shigeyoshi Inoue   +3 more
wiley   +1 more source

Rh‐Catalyzed Chemodivergent Parallel Kinetic Resolution and Desymmetrization of Enynes and Dienynes with Acrylamides

Angewandte Chemie, EarlyView.
Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada, Julong Jiang, Yu Sato, Takashi Yamazaki, Satoshi Maeda, Ken Tanaka   +5 more
wiley   +1 more source

The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications

Angewandte Chemie International Edition, EarlyView.
This work describes the synthesis of bench‐stable dicationic carboranes. Their enhanced electrophilicity is documented by opening the clusters with weak nucleophiles or dihydrogen. The surprising stability of positively charged carboranes in water enabled a study of their in vitro antiproliferative activity, which surpassed the effects of doxorubicin ...
Vlastimil Němec, Josef Holub, Maksim A. Samsonov, Zdeňka Růžičková, Josef Cvačka, Ján Vančo, Zdeněk Trávníček, Jan Belza, Zdeněk Dvořák, Jan Vrána, Aleš Růžička   +10 more
wiley   +1 more source

Design, synthesis, molecular docking and cytotoxic evaluation of novel pyrimidine-based sulfonamide derivatives as potent anticancer agents: SAR insights and biological profiling. [PDF]

Sci Rep
Bayoumy NM, Fadda AA, Gaffer HE, Soliman NN.   +3 more
europepmc   +1 more source

Mapping the Reactivity of the C═C Bond of Cyclic Enol Ether Derivatives of Sugars: Nucleophilicity Parameters of Glycals

Angewandte Chemie International Edition, EarlyView.
Endo or Exo? The first quantitative kinetic mapping of the nucleophilic reactivity of endo‐ and exo‐glycal compounds highlighted that endo‐glycals are typically 102 times less reactive than their corresponding parent cyclic enol ethers while exo‐glycals are 103 more nucleophilic. This experimental and computational structure–reactivity study highlights
Sophie Rodrigues, Saloua Chelli, Jenny Ha, Lucie Pedussaut, Sami Lakhdar, Raphaël Robiette, Stéphane P. Vincent, Guillaume Berionni   +7 more
wiley   +1 more source

Imidazole as a Pendant Reactivation Ligand Increases Efficacy Scope for Reactivation and Resurrection of Organophosphorus-Inhibited/Aged Cholinesterases by Quinone Methide Precursors. [PDF]

ACS Chem Neurosci
Lovins AR, Miller KA, Homoelle RK, Hoover HJ, McElroy CA, Callam CS, Hadad CM.   +6 more
europepmc   +1 more source

Anticancer potential of fused heterocycles: structural insights and mechanistic advances. [PDF]

Asian Biomed (Res Rev News)
Pandey A, Sharma S, Kishore K, Rani S, Singh MV, Pemawat G.   +5 more
europepmc   +1 more source

Medicinal attributes of nitrogen heterocycles directing aldose reductase selectivity and potency. [PDF]

RSC Med Chem
Kumari A, Manna SK, Rani K, Kohal R, Gupta GD, Verma SK.   +5 more
europepmc   +1 more source

[Studies on heterocyclic compounds. 3. Ring closure reaction of 4,5-diamino-6-substituted-aminopyrimidines].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1968
T, Okano, S, Goya, A, Takadate, Y, Ito
openaire   +1 more source

Development of new pyrazole-thiophene hybrids: synthesis, anticancer assessment, and molecular docking insights. [PDF]

RSC Adv
Samy S, Mahmoud SE, Abdel-Galil E, Abdel-Latif E, Said GE.   +4 more
europepmc   +1 more source