Results 311 to 320 of about 176,899 (357)

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Is Phenylnitrene a Missing Link in the Formation of Polycyclic Aromatic Nitrogen Heterocycles?

Angewandte Chemie International Edition, Accepted Article.
The incorporation of heteroatoms into the framework of polycyclic aromatic hydrocarbons (PAHs), in particular of nitrogen to yield polycyclic aromatic nitrogen heterocycles (PANHs), has been proposed for both astronomical and combustion environments, but no suitable precursors and pathways have been found.
Rahel Arns, Rory McClish, Patrick Hemberger, Andras Bodi, Jordy Bouwman, Tina Kasper, Domenik Schleier   +6 more
wiley   +1 more source

Mechanoactivated Celite as a catalyst for C‒H bond perfluoroalkylation and other radical reactions

Angewandte Chemie International Edition, Accepted Article.
Herein we report that Celite (diatomaceous earth) commonly viewed as an innocent filter aid or support material, or Earth‐abundant, non‐toxic metal oxides are efficient mechanoactivated catalysts for arene and heteroarene C‒H bond radical trifluoromethylation and pentafluoroethylation, with the activity comparable with previously reported ...
Thomas J. Hasiweder, Hoan M. Dinh, Dilip K. Pandey, Aleksandr Sorvanov, Julia Khusnutdinova   +4 more
wiley   +1 more source

Photoelectrochemical Iron(III) Catalysis for Late‐Stage C─H Fluoroalkylations

Angewandte Chemie International Edition, EarlyView.
Efficient electrophotochemical C─H fluoroalkylation of complex bioactive substrates with abundant fluoroalkyl carboxylic acids employing an inexpensive iron(III) catalyst accompanied by hydrogen evolution reaction has been developed. Abstract Chemo‐ and site‐selective functionalization of complex molecules poses a fundamental challenge.
Vladimir Motornov, Sven Trienes, Simonetta Resta, João C. A. Oliveira, Zhipeng Lin, Zhi Liu, Tristan von Münchow, Claudia Stückl, Lutz Ackermann   +8 more
wiley   +1 more source

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ChemInform Abstract: Heterocyclic Compounds

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +1 more source

Polyhalogenated heterocyclic compounds

Journal of Fluorine Chemistry, 2005
Model studies show that displacement of fluorine, rather than chlorine, occurs upon reaction of 3,5-dichloro-2,4,6-trifluoropyridine with sodium methoxide and phenoxide. Subsequent hydro-dechlorination can be achieved by reaction with lithium aluminium hydride whereas reaction of sodium in iso-propanol leads to formation of the tri-iso-propoxy pyridine
Christopher B. Murray, Graham Sandford, Andrei S. Batsanov, Richard D. Chambers, Judith A. K. Howard, Ali Kh. Khalil   +5 more
openaire   +2 more sources

ChemInform Abstract: Heterocyclic Compounds

ChemInform, 1990
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +1 more source

Heterocyclic Compounds as Inflammation Inhibitors

Current Medicinal Chemistry, 2002
Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with significant toxicity particularly in the gastrointestinal tract and kidney. Various approaches such as formulation co-administration (of agents to protect the stomach), chemical manipulation and synthesis of new safer anti-inflammatory drugs reported in the literature to ...
Sham M. Sondhi, J. William Lown, Nidhi Singhl, B.S. Narayan Reddy, Monika Johar   +4 more
openaire   +2 more sources

Heterocyclic compounds—V

Tetrahedron, 1964
Abstract Ethoxyacetylene was added to 2,3-methylenedioxyphenyl isocyanate to yield 4-ethoxy-7,8-methylenedioxy-2-quinolone. N-Methylation of the quinolone followed by hydrolysis of the ethoxy group and treatment with diazomethane gave 4-methoxy-1-methyl-7,8-methylenedioxy-2-quinolone.
B. Weinstein, T.A. Hylton
openaire   +2 more sources

ChemInform Abstract: Electrolysis of Heterocyclic Compounds

ChemInform, 1970
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +3 more sources