Results 31 to 40 of about 38,755 (208)

Group II Intron-Based Gene Targeting Reactions in Eukaryotes [PDF]

, 2008
Background: Mobile group II introns insert site-specifically into DNA target sites by a mechanism termed retrohoming in which the excised intron RNA reverse splices into a DNA strand and is reverse transcribed by the intron-encoded protein.
Mastroianni Marta, Jamie Vernon, Wallingford, John, Travis B White, White Travis B., Wallingford John, Alan M. Lambowitz, Matsuura, Manabu, Watanabe Kazuo, Matsuura Manabu, Watanabe, Kazuo, Mastroianni, Marta, Manabu Matsuura, Lambowitz Alan M., Zhuang Fanglei, Vernon, Jamie, John Wallingford, Lambowitz, Alan M., Fanglei Zhuang, Vernon Jamie, Zhuang, Fanglei, Alan M Lambowitz, White, Travis B., Kazuo Watanabe, Travis B. White, Marta Mastroianni   +25 more
core   +2 more sources

Genome-Wide Analysis of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) Binding to HIV-1 RNA Reveals a Key Role for hnRNP H1 in Alternative Viral mRNA Splicing

Journal of Virology, 2019
Alternative splicing of HIV-1 mRNAs is an essential yet quite poorly understood step of virus replication that enhances the coding potential of the viral genome and allows the temporal regulation of viral gene expression.
Sebla B. Kutluay, A. Emery, Srinivasa R. Penumutchu, Dana Townsend, Kasyap Tenneti, Michaela K. Madison, Amanda M. Stukenbroeker, Chelsea Powell, David Jannain, B. Tolbert, R. Swanstrom, P. Bieniasz   +11 more
semanticscholar   +1 more source

Functional conservation of the transportin nuclear import pathway in divergent organisms [PDF]

, 1998
Human transportin1 (hTRN1) is the nuclear import receptor for a group of pre-mRNA/mRNA-binding pro-teins (heterogeneous nuclear ribonucleoproteins [hnRNP]) represented by hnRNP A1, which shuttle continuous-ly between the nucleus and the cytoplasm.
Rain, Jean-Christophe, Dreyfuss, Gideon, Fromont, Micheline, Jean-christophe Rain, Gideon Dreyfuss, Wan, Lili, Micheline Fromont, Pierre Legrain, Legrain, Pierre, Lili Wan, Siomi, Mikiko, C., Wang, Fan, Mikiko C. Siomi, Fan Wang   +13 more
core   +1 more source

SC35 and Heterogeneous Nuclear Ribonucleoprotein A/B Proteins Bind to a Juxtaposed Exonic Splicing Enhancer/Exonic Splicing Silencer Element to Regulate HIV-1 tat Exon 2 Splicing*

Journal of Biological Chemistry, 2004
Splicing of the human immunodeficiency virus, type 1, primary transcript is highly regulated. Maintaining the proper equilibrium among spliced, unspliced, and partially spliced isoforms is essential for the replication of the virus.
A. Zahler, C. Damgaard, J. Kjems, M. Caputi   +3 more
semanticscholar   +1 more source

Differential Gene Expression and Protein–Protein Interaction Networks in Bovine Leukemia Virus Infected Cattle: An RNA-Seq Study

Pathogens
Introduction: Bovine leukemia virus is a single-stranded RNA virus that targets B cell CD5+ lymphocytes in cattle. Only a tiny percentage of individuals develop malignant lymphoproliferative disorders, while most remain healthy carriers or experience ...
Ana S. González-Méndez, Mohammad Mehdi Akbarin, Fernando Cerón-Téllez, Gabriel Eduardo Acevedo-Jiménez, Cecilia Rodríguez-Murillo, Víctor David González-Fernández, Lucero de María Ávila-De la Vega, Marisela Leal-Hernández, Hugo Ramírez Álvarez   +8 more
doaj   +1 more source

Evolutionarily Conserved Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A/B Proteins Functionally Interact with Human and Drosophila TAR DNA-binding Protein 43 (TDP-43)*

Journal of Biological Chemistry, 2014
Background: TDP-43 and hnRNPA1/A2 factors are implicated in neurodegeneration. Results: The human and fruit fly TDP-43 and hnRNPA1/A2 orthologs show physical, genetic, and functional interplays.
M. Romano, E. Buratti, Giulia Romano, Raffaella Klima, Lisa Del Bel Belluz, C. Stuani, F. Baralle, F. Feiguin   +7 more
semanticscholar   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein. [PDF]

, 1997
The hairpin structure at the 3' end of animal histone mRNAs controls histone RNA 3' processing, nucleocytoplasmic transport, translation and stability of histone mRNA.
Schümperli, Daniel, Eglite, S, Schaller, A, Martin, F, Müller, B   +4 more
core   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Repair of Aberrant Splicing in Growth Hormone Receptor by Antisense Oligonucleotides Targeting the Splice Sites of a Pseudoexon [PDF]

, 2010
Context: The GH receptor (GHR) pseudoexon 6 Psi defect is a frequent cause of GH insensitivity (GHI) resulting from a non-functioning GH receptor (GHR). It results in a broad range of phenotypes and may also be present in patients diagnosed as idiopathic
Srirangalingam, U, David, A, Metherell, LA, Khoo, B, Clark, AJL   +4 more
core