Results 21 to 30 of about 38,755 (208)

Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases

Microbiology and Molecular Biology Reviews, 2006
SUMMARY The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine (Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were originally identified as stress-activated protein kinases in the livers of
M. Bogoyevitch, B. Kobe
semanticscholar   +1 more source

Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex

Nature Communications, 2022
HNRNPU encodes the heterogeneous nuclear ribonucleoprotein U, which participates in RNA splicing and chromatin organization. Microdeletions in the 1q44 locus encompassing HNRNPU and other genes and point mutations in HNRNPU cause brain disorders ...
T. Sapir, Aditya Kshirsagar, Anna Gorelik, T. Olender, Z. Porat, I. Scheffer, D. Goldstein, O. Devinsky, O. Reiner   +8 more
semanticscholar   +1 more source

Expression of folate receptors and heterogeneous nuclear ribonucleoprotein E1 in women with human papillomavirus mediated transformation of cervical tissue to cancer [PDF]

, 2003
Aims: Folate receptors (FRs) mediate cellular uptake of folates in many cancer cells and in folate deficiency heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) mediates translational upregulation of FR in cultured cervical cancer cells.
Jayaprakash, P. G., Kesari, L. A., Antony, A. C., Pillai, M. R., Chacko, P., Jayaram, H. N.   +5 more
core   +1 more source

Host heterogeneous ribonucleoprotein K (hnRNP K) as a potential target to suppress hepatitis B virus replication. [PDF]

, 2005
BACKGROUND: Hepatitis B virus (HBV) infection results in complications such as cirrhosis and hepatocellular carcinoma. Suppressing viral replication in chronic HBV carriers is an effective approach to controlling disease progression.
Paul Chung-Pui Cheng (275197), Leung Eastwood Hon-Chiu, Eastwood Hon-Chiu Leung, Ren Ee-Chee, Marieta Chan, Wei-Ning Chen (275200), Ee-Chee Ren (4726), Chen Wei-Ning, Lisa F P Ng, Lisa F. P Ng (58070), Soh-Ha Chan, Eastwood Hon-Chiu Leung (275199), Ng Lisa F. P, Cheng Paul Chung-Pui, Soh-Ha Chan (275196), Wei-Ning Chen, Paul Chung-Pui Cheng, Ee-Chee Ren, Marieta Chan (275194), Chan Marieta, Chan Soh-Ha   +20 more
core   +1 more source

Serine-Arginine (SR) Protein-like Factors That Antagonize Authentic SR Proteins and Regulate Alternative Splicing*

Journal of Biological Chemistry, 2001
We have characterized two RNA-binding proteins, of apparent molecular masses of ∼40 and 35 kDa, which possess a single N-terminal RNA-recognition motif (RRM) followed by a C-terminal domain rich in serine-arginine dipeptides.
A. Cowper, J. Cáceres, A. Mayeda, G. Screaton   +3 more
semanticscholar   +1 more source

Elevated Heterogeneous Nuclear Ribonucleoprotein C Expression Correlates With Poor Prognosis in Patients With Surgically Resected Lung Adenocarcinoma

Frontiers in Oncology, 2021
Background Lung adenocarcinoma (LUAD), as the most common histological subtype of lung cancer, is a high-grade malignancy and a leading cause of cancer-related death globally.
W. Guo, Qilin Huai, Guochao Zhang, Lei Guo, P. Song, X. Xue, F. Tan, Q. Xue, Shugeng Gao, Jie He   +9 more
semanticscholar   +1 more source

S-Nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.

Journal of Biological Chemistry, 2017
Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of (cid:1) 298 amino acids that contains a Gly-Arg-Gly-Asp-Ser sequence.
Chengjiang Gao, Hongtao Guo, Junping Wei, Z. Mi, P. Wai, P. Kuo   +5 more
semanticscholar   +1 more source

The heterogeneous nuclear ribonucleoproteins I and K interact with a subset of the ro ribonucleoprotein-associated Y RNAs in vitro and in vivo. [PDF]

, 2001
The hY RNAs are a group of four small cytoplasmic RNAs of unknown function that are stably associated with at least two proteins, Ro60 and La, to form Ro ribonucleoprotein complexes.
Fabini, G, Fouraux, M.A., Raijmakers, R., Steiner, G., Hayer, S, Pruijn, G.J.M.   +5 more
core   +1 more source

TDP-43 Binds Heterogeneous Nuclear Ribonucleoprotein A/B through Its C-terminal Tail

Journal of Biological Chemistry, 2005
TDP-43 is a highly conserved nuclear factor of yet unknown function that binds to ug-repeated sequences and is responsible for cystic fibrosis transmembrane conductance regulator exon 9 splicing inhibition. We have analyzed TDP-43 interactions with other
E. Buratti, Antonia Brindisi, Maurizio Giombi, S. Tisminetzky, Y. Ayala, F. Baralle   +5 more
semanticscholar   +1 more source

CRNDE mediated hnRNPA2B1 stability facilitates nuclear export and translation of KRAS in colorectal cancer [PDF]

, 2023
Development of colorectal cancer (CRC) involves activation of Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling. However, the post-transcriptional regulation of KRAS has yet to be fully characterized.
Jianzhong Wu, Ya Lu, Quan Gu, Xinyue Wang, Renrui Zou, Junying Zhang, Rong Ma, Ting Wang, Jifeng Feng, Yuan Zhang   +9 more
core   +1 more source