Results 1 to 10 of about 38,755 (208)

Heterogeneous nuclear ribonucleoprotein A/B: an emerging group of cancer biomarkers and therapeutic targets

Cell Death Discovery, 2022
Heterogeneous nuclear ribonucleoprotein A/B (hnRNPA/B) is one of the core members of the RNA binding protein (RBP) hnRNPs family, including four main subtypes, A0, A1, A2/B1 and A3, which share the similar structure and functions.
Ya Lu, Xinyue Wang, Quan Gu, Juan Wang, Ying Sui, Jianzhong Wu, Jifeng Feng   +6 more
doaj   +4 more sources

Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons [PDF]

Cell Reports, 2023
Summary: Spatiotemporal control of gene expression is important for neural development and function. Here, we show that heterogeneous nuclear ribonucleoprotein (hnRNP) A/B is highly expressed in developing olfactory sensory neurons (OSNs), and its ...
Nanaho Fukuda, Tomoyuki Fukuda, Piergiorgio Percipalle, Kanako Oda, Nobuyuki Takei, Kevin Czaplinski, Kazushige Touhara, Yoshihiro Yoshihara, Toshikuni Sasaoka   +8 more
doaj   +3 more sources

Altered Expression and Localization of Creatine Kinase B, Heterogeneous Nuclear Ribonucleoprotein F, and High Mobility Group Box 1 Protein in the Nuclear Matrix Associated with Colon Cancer [PDF]

Cancer Research, 2006
Abstract Identification of biomarkers could lead to the development of effective screening tests for colorectal cancer. A previous study from our laboratory showed specific alterations of nuclear structure in colon cancer. In an effort to characterize these biomarkers, protein spots were selected from separations made by two-dimensional ...
Manimalha, Balasubramani, Billy W, Day, Robert E, Schoen, Robert H, Getzenberg   +3 more
openaire   +3 more sources

Structure of nuclear ribonucleoprotein: identification of proteins in contact with poly(A)+ heterogeneous nuclear RNA in living HeLa cells.

Journal of Cell Biology, 1981
The processing of heterogeneous nuclear RNA into messenger RNA takes place in special nuclear ribonucleoprotein particles known as hnRNP. We report here the identification of proteins tightly complexed with poly(A)+ hnRNA in intact HeLa cells, as ...
B Setyono, J R Greenberg, Thoru Pederson   +2 more
exaly   +2 more sources

The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies

Frontiers in Immunology, 2021
B-cell lymphomas are one of the most biologically and molecularly heterogeneous group of malignancies. The inherent complexity of this cancer subtype necessitates the development of appropriate animal model systems to characterize the disease with the ...
Prerna Malaney, María Velasco-Estevez, Pedro Aguilar-Garrido, Marisa J. L. Aitken, Lauren E. Chan, Xiaorui Zhang, Sean M. Post, Miguel Gallardo   +7 more
doaj   +1 more source

Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity.

Cellular and Molecular Biology, 2023
The occurrence and progression of intestinal cancer are complex, multifactorial processes in which tumor stem cells are believed to play a crucial role.
Meng Wang, Xian Wang, Yaping Cui, Xing Wen   +3 more
semanticscholar   +1 more source

New roles of N6-methyladenosine methylation system regulating the occurrence of non-alcoholic fatty liver disease with N6-methyladenosine-modified MYC

Frontiers in Pharmacology, 2022
Non-alcoholic fatty liver disease (NAFLD) has become a major chronic disease in contemporary society, affected by N6-methyladenosine (m6A) RNA methylation, one of the most common RNA modifications. Compared with healthy control, m6A RNA methyltransferase
Wenli Cheng, Min Li, Luyun Zhang, Cheng Zhou, Susu Yu, Xinyue Peng, Wenji Zhang, Wenjuan Zhang   +7 more
doaj   +1 more source

Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis

bioRxiv, 2023
Genetic variants affecting Heterogeneous Nuclear Ribonucleoprotein U (HNRNPU) have been identified in several neurodevelopmental disorders (NDDs). HNRNPU is widely expressed in the human brain and shows the highest postnatal expression in the cerebellum.
F. Mastropasqua, M. Oksanen, C. Soldini, Shemim Alatar, Abishek Arora, Roberto Ballarino, Maya Molinari, F. Agostini, Axel Poulet, M. Watts, I. Rabkina, Martin Becker, Danyang Li, B. Anderlid, J. Isaksson, K. L. Remnélius, M. Moslem, Yannick Jacob, Anna Falk, N. Crosetto, M. Bienko, E. Santini, A. Borgkvist, S. Bölte, K. Tammimies   +24 more
semanticscholar   +1 more source

Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity

Life Science Alliance, 2021
hnRNP E1 binds polycytosine tracts of DNA and monitors genome integrity. Heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) is a tumor suppressor protein that binds site- and structure-specifically to RNA sequences to regulate mRNA stability ...
B. Mohanty, J. Karam, B. Howley, A. Dalton, S. Grelet, T. Dincman, W. S. Streitfeld, Je-Hyun Yoon, Lata Balakrishnan, W. Chazin, David T. Long, P. Howe   +11 more
semanticscholar   +1 more source

Deletion of heterogeneous nuclear ribonucleoprotein F in renal tubules downregulates SGLT2 expression and attenuates hyperfiltration and kidney injury in a mouse model of diabetes

Diabetologia, 2021
We previously reported that renal tubule-specific deletion of heterogeneous nuclear ribonucleoprotein F (Hnrnpf) results in upregulation of renal angiotensinogen (Agt) and downregulation of sodium-glucose co-transporter 2 (Sglt2) in HnrnpfRT knockout (KO)
Kana N. Miyata, Chao-Sheng Lo, Shui-Ling Zhao, Xin-Ping Zhao, Isabelle Chénier, M. Yamashita, J. Filep, J. Ingelfinger, Shao-Ling Zhang, J. Chan   +9 more
semanticscholar   +1 more source