Results 61 to 70 of about 143,250 (293)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Frustrated Lewis Pairs in Heterogeneous Catalysis: Theoretical Insights

Molecules, 2022
Frustrated Lewis pair (FLP) catalysts have attracted much recent interest because of their exceptional ability to activate small molecules in homogeneous catalysis.
Qiang Wan, Sen Lin, Hua Guo
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Supported Gold Nanoparticles for Alcohols Oxidation in Continuous-Flow Heterogeneous Systems [PDF]

, 2017
Gold nanoparticles (AuNPs) were anchored on alkynyl carbamate-functionalized support materials having the suitable features for application as catalysts in continuous-flow packed bed reactors.
Ballarin, Barbara, BARRECA, DAVIDE, Boanini, Elisa, Cassani, Maria Cristina, Dambruoso, Paolo, Massi, Alessandro, Mignani, Adriana, Nanni, Daniele, Parise, Chiara, Zaghi, Anna   +9 more
core   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Green electrochemical fabrication of WO3 nanostructures using Cistus extracts for enhanced photoelectrocatalytic degradation of ciprofloxacin

Chemical Engineering Journal Advances
The development of sustainable fabrication routes for advanced semiconductor materials is crucial for environmental technology. This work presents a green electrochemical anodization strategy to fabricate tungsten trioxide (WO3) nanostructures, employing
Gemma Roselló-Márquez, Elianny Da Silva, Dionisio M. García-García, Benjamin Solsona, Rita Sánchez-Tovar, Ramón M. Fernández-Domene   +5 more
doaj   +1 more source

A Practical Guide to Surface Kinetic Monte Carlo Simulations [PDF]

, 2019
This review article is intended as a practical guide for newcomers to the field of kinetic Monte Carlo (KMC) simulations, and specifically to lattice KMC simulations as prevalently used for surface and interface applications.
Andersen, Mie, Panosetti, Chiara, Reuter, Karsten   +2 more
core   +3 more sources

Advancing Electronic Application of Coordination Solids: Enhancing Electron Transport and Device Integration via Surface‐Mounted MOFs (SURMOFs)

Advanced Functional Materials, Volume 36, Issue 43, 29 May 2026.
The layer‐by‐layer (LbL) assembly of coordination solids, enabled by the surface‐mounted metal‐organic framework (SURMOF) platform, is on the cusp of generating the organic counterpart of the epitaxy of inorganics. The programmable and sequential SURMOF protocol, optimized by machine learning (ML), is suited for accessing high‐quality thin films of ...
Zhengtao Xu, Christof Wöll, Stefan Bräse   +2 more
wiley   +1 more source

An Efficient PdPt/rGO Catalyst for Hydrogen Electrolysis in Acidic Medium: Structure‐Activity Relationships and CO‐Tolerance

ChemElectroChem
The reliable conversion and utilization of green hydrogen are often hindered by carbon monoxide (CO) impurities, which strongly poison conventional platinum catalysts in acidic media.
Shwetambara Jha, Chalachew Mebrahtu, Felix Ott, Cheng Jiang, Heinrich Hartmann, Regina Palkovits   +5 more
doaj   +1 more source