Results 71 to 80 of about 4,599,562 (265)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Gibbs-Sampling-based Optimization for the Deployment of Small Cells in 3G Heterogeneous Networks [PDF]

, 2013
The growing popularity of mobile data services has placed great demands for wireless cellular networks to support higher-throughput. One way to meet the rapidly growing traffic demand is through heterogeneous network deployment, which uses a mixture of ...
Wang, Chih-Chun, Lin, Xiaojun, li, Xiaohang, Tang, Xiaojun   +3 more
core   +1 more source

Single-cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks involved In the Central Circadian Clock

Frontiers in Neuroscience, 2016
Single-cell heterogeneity confounds efforts to understand how a population of cells organizes into cellular networks that underlie tissue-level function. This complexity is prominent in the mammalian suprachiasmatic nucleus (SCN).
James Park, James Park, Haisun Zhu, Sean O'Sullivan, Sean O'Sullivan, Babatunde Ogunnaike, David Weaver, James Schwaber, James Schwaber, Rajanikanth Vadigepalli, Rajanikanth Vadigepalli   +10 more
doaj   +1 more source

Physical Layer Security in Heterogeneous Cellular Networks [PDF]

IEEE Transactions on Communications, 2016
The heterogeneous cellular network (HCN) is a promising approach to the deployment of 5G cellular networks. This paper comprehensively studies physical layer security in a multi-tier HCN where base stations (BSs), authorized users and eavesdroppers are all randomly located.
Hui-Ming Wang 0001, Tongxing Zheng, Jinhong Yuan, Don Towsley, Moon Ho Lee   +4 more
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Handoff modeling in cellular CDMA with finite sources and state-dependent bandwidth requirements [PDF]

, 2014
It is envisioned that small cells are going to play an important role in future cellular networks. Due to limited coverage areas of small cells and increased user mobility, a proper analysis and evaluation of handoff traffic is of major importance.
Vasilakis, Vasileios, Moscholios, Ioannis, Logothetis, Michael, Vassilakis, Vassilios, Ioannis D. Moscholios, Vardakas, John, Michael D. Logothetis, Vassilios G. Vassilakis, John S. Vardakas   +8 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

User-In-The-Loop Content Delivery in Cellular Communication Networks with Heterogeneous User Behaviors

Applied Sciences, 2018
User-in-the-loop (UiL) content delivery is a recently proposed scheme for personalized content retrieval over mobile communication networks. It is a promising scheme that can better manage the overall user quality-of-experience (QoE) throughout the ...
Weicheng Zhang, Yaodong Li, Hai Lu, Xuemin Hong, Jianghong Shi   +4 more
doaj   +1 more source

Interference Management in Heterogeneous Cellular Networks

, 2016
Heterogeneous cellular networks (HetNets), comprising one or more tiers of small base stations (BSs) overlaid on the tier of well-planned macro BSs, have been commonly recognized as a cost-effective solution to cater to explosive demands on mobile data traffic. However, HetNets also bring some unique challenges such as unplanned deployment of small BSs
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source