Results 91 to 100 of about 27,386 (301)

Optimal Cycles and Social Inequality: What Do We Learn from the Gini Index? [PDF]

One of the plausible explanations for macroeconomic fluctuations relies on the occurrence of endogenous deterministic cycles. In the last three decades, most of the relevant literature has rested on the assumption of a representative agent but, recently,
Stefano Bosi, Thomas Seegmuller
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Family Tax Policy with Heterogeneous Altruistic Households

, 2017
This paper presents a general equilibrium model, with overlapping generations and heterogeneous altruistic households. Taking into account the heterogeneity of households allows one to develop an alternative framework to explain why empirical estimations
Granelli, Lucia
core  

The influence of external finance and domestic investment on clean energy transitions for African urban and rural households

Discover Sustainability
This study examines the determinants of household energy transition in 48 African countries (2000–2023), focusing on domestic investment and external finance roles.
Gildas Dohba Dinga, Gisele Mah
doaj   +1 more source

Modelling Consumer Demand in Intermittent Water Supply (IWS) Networks: Evidence from Nepal

Engineering Proceedings
Modelling consumer demand under intermittent water supply (IWS) is an unresolved challenge. To understand withdrawal behaviours in more detail, fifty-six smart meters were installed in households across an IWS network in Lahan, Nepal.
Matthew MacRorie, Sally Weston, Kabindra Pudasaini, Robin Price, Vanessa Speight, Richard Collins   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Welfare-improving Government Behaviour and Inequality - Inspection Using a Heterogeneous-agent Model [PDF]

Governments behavior is expected to be non-neutral in terms of impacts on both welfare and inequality. In spite of their multivariate form, a tentative assessment of such inequality impacts can be provided by using a general equilibrium model with ...
Ana Paula Ribeiro, Miguel Viegas
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Development of a territory-wide household-based composite index for measuring relative distribution of households by economic status in individual small areas throughout Hong Kong

BMC Public Health
Background Many countries have developed their country/nation-wide multidimensional area-based index on deprivation or socioeconomic status for resource allocation, service planning and research.
Eva L.H. Tsui, Philip L.H. Yu, K. F. Lam, Kelvin K.Y. Poon, Adam C.M. Ng, K. Y. Cheung, Winnie Li, Michael L.H. Leung, David H.Y. Lam, James L.Y. Cheng, Sharon P.W. Ng   +10 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source