Results 81 to 90 of about 23,495 (217)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Beyond eating cessation: Monte Carlo analysis of food inflation impacts in Nairobi's informal settlements

Journal of the Saudi Society of Agricultural Sciences
This study examines the resilience of Nairobi’s low-income households to food price and income shocks using high-resolution expenditure data from 302 households across nine informal settlements.
Gabriel Mwenjeri, Kariuki Josphat Muiruri, Florence Miima Abuyeka   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Medical insurance, vulnerability to poverty, and wealth inequality

Frontiers in Public Health
BackgroundChina has made remarkable achievements in alleviating poverty under its current poverty standards. Despite these immense successes, the challenge of consolidating these achievements remains.
Xianhua Zhou, Xujin Yang
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Designing Efficient Sample Strata Through Application of Random Forest Classifiers to Administrative and Survey Data

Data Science in Science
Surveys aiming to oversample certain classes of households to reduce the variance of estimates for small subgroups typically randomly oversample units in geographies where the characteristic(s) of interest are more densely concentrated.
Jonathan Eggleston, Linden McBride, Mark Klee   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Does the targeted poverty alleviation program improve the subjective well-being of poor households? Empirical evidence from China

Frontiers in Public Health
Enhancing the subjective well-being of poor households is crucial for the world’s sustainable development. Using a comprehensive household-level dataset from the China Household Finance Survey (CHFS) spanning 2011 to 2019, this study employed a multi ...
Dazhe Wang, Xiaolei Yang
doaj   +1 more source

Heterogeneous Households A within-subject test of asymmetric information between spouses in Kenya. [PDF]

J Econ Behav Organ, 2015
Hoel JB.
europepmc   +1 more source