Results 71 to 80 of about 175,206 (343)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Financial inclusion and expenditure patterns: Insights from slum households in Bangladesh
Cogent Economics & FinanceVulnerable households often tend to decrease their human capital expenditures, like education and training, to maintain food and non-food (clothing and housing) expenditures when any income shock occurs.
MD Abdul Bari +4 more
doaj +1 more source
Social network and tourism consumption by households: Evidence from China.
PLoS ONE, 2022 Tourism consumption is not only an important means by which to improve residents' sense of happiness but is also the main way to promote national economic development.
Genjin Sun +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
EconomiesThis study assesses the effects of the COVID-19 pandemic on catastrophic health expenditures and income inequality in Benin. A microsimulation was calibrated to estimate the impact of the pandemic under three different shock scenarios: low, moderate, and
Albert N. Honlonkou +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Espace populations sociétés, 2015 Speaking of routines, in social sciences easily carries connotations related to alienation. Routines, it is said, come from the fact that individuals and households, depend on heavy macro-social time constraints that impose their mechanical time on their
Frédéric de Coninck
doaj +1 more source
Environmental heterogeneity and commodity sharing in smallholder agroecosystems.
PLoS ONE, 2020 Smallholder farmers undertake a number of strategies to cope with climate shocks in a community. The sharing of resources across households constitutes one coping mechanism when environmental shocks differentially impact households.
Stacey A Giroux +8 more
doaj +1 more source