Results 101 to 110 of about 10,669 (267)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The Effective Number of Degrees of Freedom of the Far-Fields Radiated by Rectangular Current Sheets

IEEE Open Journal of Antennas and Propagation
The number of degrees of freedom (NDF) of the electromagnetic far-fields generated by current sheets under certain noise level in the environment is evaluated numerically by directly sampling on the constellation of the propagation modes in free space ...
Ting Zang, Gaobiao Xiao
doaj   +1 more source

Development of Semantics-Based Distributed Middleware for Heterogeneous Data Integration and its Application for Drought [PDF]

Adeyinka K. Akanbi
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Miniaturized Ultrawide Stopband Single-Band Filter and Large Frequency Ratio Dual-Band Filter Based on Inhomogeneous Half-Mode T-Septum Waveguide

IEEE Journal of Microwaves
The inhomogeneous half-mode T-septum waveguide (IHMTSG) cavity is analyzed and applied to the design of miniaturized single- and dual-band band-pass filters (BPFs) in this paper.
Zi-Qi Zhang, Liang Zhou
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Integrating a Heterogeneous Graph with Entity-aware Self-attention using Relative Position Labels for Reading Comprehension Model [PDF]

, 2023
Shima Foolad, Kourosh Kiani
openalex   +1 more source

Heterogeneous Nonlinear Integrated Photonics

IEEE Journal of Quantum Electronics, 2018
Integrated photonics has been pursued on a large variety of materials and platforms over more than half a century. In recent decades, silicon has emerged as the preferred optical and substrate material. However, since many optical functionalities cannot be, inherently or conveniently, implemented on silicon-based devices, heterogeneous integration of ...
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Spatiotemporal modulation of ultrafast plasmonic vortices with spin–orbit coupling

New Journal of Physics
The vortex field of surface plasmon polariton with orbital angular momentum (OAM), called plasmonic vortex, has played an important role in various research fields.
Weipeng Li, Shuoshuo Zhang, Zhangyu Zhou, Yanan Fu, Yuquan Zhang, Xiaocong Yuan, Changjun Min   +6 more
doaj   +1 more source