Results 111 to 120 of about 882,435 (290)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Profile likelihood analysis for a stochastic model of diffusion in heterogeneous media. [PDF]

Proc Math Phys Eng Sci, 2021
Simpson MJ, Browning AP, Drovandi C, Carr EJ, Maclaren OJ, Baker RE.   +5 more
europepmc   +1 more source

A new approach to the homogenization of heterogeneous media for neutron diffusion calculations [PDF]

Mathematical formulation for homogenization of heterogeneous media for neutron diffusion transport ...
Jacobs, A. M.
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Some comparisons and analyses of time or space discontinuous Galerkin methods applied to elastic wave propagation in anisotropic and heterogeneous media

Advanced Modeling and Simulation in Engineering Sciences, 2019
This research work presents some comparisons and analyses of the time discontinuous space–time Galerkin method and the space discontinuous Galerkin method applied to elastic wave propagation in anisotropic and heterogeneous media.
Bing Tie
doaj   +1 more source

mSOUND: An Open Source Toolbox for Modeling Acoustic Wave Propagation in Heterogeneous Media. [PDF]

IEEE Trans Ultrason Ferroelectr Freq Control, 2021
Gu J, Jing Y.
europepmc   +1 more source

Domain Decomposition for Heterogeneous Media [PDF]

, 2007
Elliptic problems with multiscale coefficients have been studied to a great extent recently. Preconditioners based on standard domain decomposition methods often perform poorly when the variation of the coefficients inside the subdomains is large. In this paper we study the behaviour of domain decomposition methods based on linear coarsening for such ...
Ivan G. Graham, Patrick O. Lechner
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Bounding of Flow and Transport Analysis in Heterogeneous Saturated Porous Media: A Minimum Energy Dissipation Principle for the Bounding and Scale-Up

Hydrology, 2019
We apply minimum kinetic energy principles from classic mechanics to heterogeneous porous media flow equations to derive and evaluate rotational flow components to determine bounding homogenous representations.
R. William Nelson, Gustavious P. Williams   +1 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source