Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Comparing Dose Calculation Algorithms for Heterogeneous Media: Analytical Anisotropic Algorithm Versus Acuros XB (Dm/Dw) With Continuous CT Value Variation. [PDF]
Cureus, 2023 Yanagi Y +6 more
europepmc +1 more source
An Improved Method for Reconstructing the Digital Core Model of Heterogeneous Porous Media
, 2018 The heterogeneous pore space of porous media strongly affects the storage and migration of oil and gas in the reservoir. In this paper, the cross-correlation-based simulation (CCSIM) is combined with the three-step sample method to reconstruct ...
林缅, 江文滨, Wu CJ, 姬莉莉
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Study of wave propagation in discontinuous and heterogeneous media with the dynamic lattice method. [PDF]
Sci Rep, 2022 Sattari AS, Rizvi ZH, Aji HDB, Wuttke F.
europepmc +1 more source
Time domain random walks for hydrodynamic transport in heterogeneous media
, 2016 International audienceWe derive a general formulation of the time domain random walk (TDRW) approach to model the hydrodynamic transport of inert solutes in complex geometries and heterogeneous media.
Dentz, Marco +2 more
core +1 more source
Estimation of the Effective Permeability of Heterogeneous Porous Media by Using Percolation Concepts [PDF]
, 2016 In this paper we present new methods to estimate the effective permeability (k_eff) of heterogeneous porous media with a wide distribution of permeabilities and various underlying structures, using percolation concepts.
P. R. King +5 more
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Stochastic Lattice Model of Aggregation in Heterogeneous Polydisperse Media
Chemical Engineering Transactions, 2017 The submitted paper proposes a new model algorithmic approach to describing aggregation processes, which is based on mathematical tool of a random walk over mathematical lattices. Such approach agrees as a whole with the DES paradigm.
A. Brener +2 more
doaj +1 more source
Voxel-S-value methods adapted to heterogeneous media for quantitative Y-90 microsphere radioembolization dosimetry. [PDF]
Z Med Phys, 2023 Chen G, Lu Z, Chen Y, Mok GSP.
europepmc +1 more source