Results 101 to 110 of about 321,248 (311)
Geophysical Research Letters, 2020 Coupled effects of wettability and pore geometry on pore‐scale dynamics of immiscible two‐phase fluid displacement were investigated using a multiphase lattice Boltzmann model in homogeneous and heterogeneous porous media under a wide range of contact ...
Sahar Bakhshian +3 more
doaj +1 more source
Catastrophic Rupture Induced Damage Coalescence in Heterogeneous Brittle Media
, 2004 In heterogeneous brittle media, the evolution of damage is strongly influenced by the multiscale coupling effect. To better understand this effect, we perform a detailed investigation of the damage evolution, with particular attention focused on the ...
汪海英 +4 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Literacy at play: An analysis of media literacy games used to foster media literacy competencies [PDF]
, 2023 Media literacy is considered one of the key competencies to acquire in the 21st century. With games being recognized as having a large potential to train and educate, a wide range of games focusing on media literacy related topics such as fake news games,
Glas, René +4 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Heterogeneous Data Alignment for Cross-Media Computing [PDF]
, 2020 Massive data sets are generated everyday, and knowledge spreading trends to involve diverse media types and information sources. The new situation emerges some new challenging research problems: (1) How to bridge the heterogeneity and mine the shared ...
Shikui Wei +4 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Analysis of the Equilibrium Distribution of Ligands in Heterogeneous Media-Approaches and Pitfalls. [PDF]
Int J Mol Sci, 2022 Moreno MJ +4 more
europepmc +1 more source
, 2006 Practically every groundwater flow simulator in use today implements Darcy's law to model saturated flow [1, 4, 64, 65]. Darcy's law is a linear relation derived experimentally in the mid 1800's by Henry Darcy.
Reese, Jill Paula
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