Results 141 to 150 of about 616,266 (317)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Synthesizing Energy-Efficient Embedded Systems with LOPOCOS

, 2002
In this paper, we introduce the LOPOCOS (Low Power Co-synthesis) system, a prototype CAD tool for system level co-design. LOPOCOS targets the design of energy-efficient embedded systems, implemented as heterogeneous distributed architectures.
Al-Hashimi, Bashir M, Eles, Petru, Schmitz, Marcus T   +2 more
core  

Amyloid-induced mitochondrial network disruption in neurons monitored by STED super-resolution imaging

Frontiers in Cell and Developmental Biology
IntroductionDisruptions in mitochondrial metabolism are accompanied by morphological changes in mitochondrial network caused by amyloid-beta (Aβ). In the study, mitochondrial network analysis is performed using stimulated emission depletion (STED) super ...
Iuliia Golovynska, Qinglin Chen, Yurii V. Stepanov, Danying Lin, Junle Qu   +4 more
doaj   +1 more source

Spatial molecular-dynamically ordered NMR spectroscopy of intact bodies and heterogeneous systems. [PDF]

Commun Chem, 2020
Ito K, Tsuboi Y, Kikuchi J.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Load balancing of irregular parallel applications on heterogeneous computing environments

, 2012
Large-scale heterogeneous distributed computing environments (such as Computational Grids and Clouds) offer the promise of access to a vast amount of computing resources at a relatively low cost.
Janjic, Vladimir
core  

High-Level Reconfigurable Embedded System Design Based on Heterogeneous Models of Computation

IEEE Access
One of the main challenges of embedded system design lies in the natural heterogeneity of these systems. We can say that embedded systems are electronic systems designed and programmed to tackle a specific application.
Gabriel C. Duarte, Denis S. Loubach, Ingo Sander   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Complex Dynamics in a Bertrand Duopoly Game with Heterogeneous Players [PDF]

A heterogeneous Bertrand duopoly game with bounded rational and adaptive players manufacturing differentiated products is subject of investigation. The main goal is to demonstrate that participation of one bounded rational player in the game suffices to ...
Tomasz Dubiel-Teleszyński
core  

Integrating heterogeneous embedded systems through language translation and abstraction

, 2015
The paper summarizes a bottom-up modeling and simulation methodology that starts from heterogeneous models written in heterogeneous languages and it composes them into a homogenous system-level description by exploiting automatic translation and ...
FUMMI, Franco, F. Fummi
core   +1 more source