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Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study

open access: yesHuman Vaccines & Immunotherapeutics, 2022
In light of intermittent supply shortages of individual vaccines and evidence of rare but serious adverse events after vaccination, heterologous regimens for COVID-19 vaccines have gained significant interest. This study aims to assess the reactogenicity
Nasamon Wanlapakorn   +11 more
doaj   +2 more sources

Past Life and Future Effects—How Heterologous Infections Alter Immunity to Influenza Viruses

open access: yesFrontiers in Immunology, 2018
Influenza virus frequently mutates due to its error-prone polymerase. This feature contributes to influenza virus’s ability to evade pre-existing immunity, leading to annual epidemics and periodic pandemics.
Aisha Souquette, Paul G Thomas
exaly   +3 more sources

Heterologous immunity between viruses [PDF]

open access: yesImmunological Reviews, 2010
Summary:  Immune memory responses to previously encountered pathogens can sometimes alter the immune response to and the course of infection of an unrelated pathogen by a process known as heterologous immunity. This response can lead to enhanced or diminished protective immunity and altered immunopathology.
Michael Brehm, Liisa K Selin
exaly   +5 more sources

Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to Infections

open access: yesFrontiers in Immunology, 2019
The central paradigm of vaccination is to generate resistance to infection by a specific pathogen when the vacinee is re-exposed to that pathogen. This paradigm is based on two fundamental characteristics of the adaptive immune system, specificity and ...
Babita Agrawal, Kaihu Yao
exaly   +2 more sources

Heterologous expression of bacterial natural product biosynthetic pathways

open access: yesNatural Product Reports, 2019
Covering: 2013 to June 2018Heterologous expression of natural product biosynthetic pathways is of increasing interest in microbial biotechnology, drug discovery and optimization. It empowers not only the robust production of valuable biomolecules in more
Chengzhang Fu, Liujie Huo, Joachim J Hug
exaly   +2 more sources

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