Results 101 to 110 of about 440,074 (404)

T and B cell responses in different immunization scenarios for COVID-19: a narrative review

Frontiers in Immunology
Vaccines against COVID-19 have high efficacy and low rates of adverse events. However, none of the available vaccines provide sterilizing immunity, and reinfections remain possible.
Eva Piano Mortari, Francesca Ferrucci, Irini Zografaki, Rita Carsetti, Luciano Pacelli   +4 more
doaj   +1 more source

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes [PDF]

, 2002
A helper-dependent expression system based on transmissible gastroenteritis coronavirus (TGEV) has been developed using a minigenome of 3·9 kb (M39).
Alonso, S., Balasch, M., Enjuanes, L., Izeta, A., Moormann, R.J.M., Plana Duran, J., Reimann, I., Sola, I., Teifke, J.P.   +8 more
core   +3 more sources

The Case for Exploiting Cross-Species Epitopes in Malaria Vaccine Design

Frontiers in Immunology, 2020
The infection dynamics between different species of Plasmodium that infect the same human host can both suppress and exacerbate disease. This could arise from inter-parasite interactions, such as competition, from immune regulation, or both.
Catherine J. Mitran, Stephanie K. Yanow, Stephanie K. Yanow   +2 more
doaj   +1 more source

Lasso Peptides: Heterologous Production and Potential Medical Application

Frontiers in Bioengineering and Biotechnology, 2020
Lasso peptides are natural products found in bacteria. They belong to a specific family of ribosomally-synthesized and posttranslationally-modified peptides with an unusual lasso structure.
Cheng Cheng, Z. Hua
semanticscholar   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

High‐Resolution Genomic Resources for Trait Mapping and Precision Breeding for Adzuki Bean (Vigna angularis)

Advanced Science, EarlyView.
This study establishes crucial genomic resources for adzuki bean, including a reference genome, variation map, and the AdzukiBeanAtlas toolkit. We identify key candidate genes (ANKRD50, NAC73, ANR1, NPF5.4) for important agronomic traits through Genome‐Wide Association Studies (GWAS).
Liangliang Hu, Xiaolei Wang, Yazhou Zhang, Vanika Garg, Xingxing Yuan, Renfeng Xue, Hongmei Zhou, Yanhua Chen, Weili Hu, Rutwik Barmukh, Rong Cao, Tianxiao Chen, Qiannan Song, Dan Gao, Gaoling Luo, Xu Zhu, Xin Jing, Suhua Wang, Caiju Li, Yunshan Wei, Weide Ge, Xin Chen, Lixia Wang, Rajeev K Varshney, Chengzhi Jiao, Xuzhen Cheng, Honglin Chen   +26 more
wiley   +1 more source

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

The Lancet, 2021
D. Logunov, I. Dolzhikova, D. Shcheblyakov, A. Tukhvatulin, O. Zubkova, A. Dzharullaeva, A. Kovyrshina, N. Lubenets, D. Grousova, A. Erokhova, A. G. Botikov, F. Izhaeva, O. Popova, T. Ozharovskaya, I. Esmagambetov, I. Favorskaya, D. Zrelkin, Daria V. Voronina, D. Shcherbinin, A. Semikhin, Y. Simakova, E. Tokarskaya, D. Egorova, M. M. Shmarov, N. Nikitenko, V. Gushchin, E. Smolyarchuk, S. Zyryanov, S. Borisevich, B. Naroditsky, A. Gintsburg   +30 more
semanticscholar   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, EarlyView.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

Expansive evolution of the TREHALOSE-6-PHOSPHATE PHOSPHATASE gene family in Arabidopsis [PDF]

, 2012
Trehalose is a nonreducing sugar used as a reserve carbohydrate and stress protectant in a variety of organisms. While higher plants typically do not accumulate high levels of trehalose, they encode large families of putative trehalose biosynthesis genes.
Avonce, Nelson, Beeckman, Tom, Feil, Regina, Lammens, Willem, Lopez Galvis, Lorena, Lunn, John E, Maere, Steven, Rolland, Filip, Van Dijck, Patrick, Vandesteene, Lies, Vanneste, Kevin   +10 more
core   +2 more sources