Results 161 to 170 of about 186,962 (263)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Metastatic melanoma with heterologous bone after neoadjuvant immunotherapy: diagnostic insights. [PDF]

Pathologica
Pepe L, Fiorentino V, Ieni A, Santarpia M, Fazio A, Vaccaro M, Borgia F, Ferrara G, Lentini M.   +8 more
europepmc   +1 more source

Debneyol decoded: A metabolic organizer powers broad‐spectrum plant defense

New Plant Protection, EarlyView.
Abstract A new Cell study by Wang et al. resolves the long‐elusive biosynthesis and regulation of debneyol, a fungicidal sesquiterpenoid phytoalexin in Solanaceae. The authors define the complete three‐step route from farnesyl pyrophosphate to debneyol and identify the small protein MCD1 as a metabolic organizer that assembles a multienzyme complex to ...
Shaojie Han
wiley   +1 more source

A predictive model for rapid assessment of protective efficacy against emerging SARS-CoV-2 variants. [PDF]

Infect Dis Model
Jin L, Jia S, Shao C, Shen R, Jin P, Li J.   +5 more
europepmc   +1 more source

Speciation with gene flow

PLANTS, PEOPLE, PLANET, EarlyView.
Biodiversity is threatened by human activities, with extinction debt accumulating rapidly. Many of these activities change the connectivity of populations, fragmenting existing population systems or bringing previously isolated populations or species into contact.
Zhiqin Long, Xu Zhang, Yue Yu, Gregory L. Owens, Diana J. Rennison, Clarisse Palma‐Silva, Daniel Ortiz‐Barrientos, Loren H. Rieseberg   +7 more
wiley   +1 more source

Heterologous saRNA prime - multivalent protein boost strategy induces broad and durable immunity against SARS-CoV-2 and MERS-CoV. [PDF]

Sci Rep
Renn D, McPartlan JS, Banala S, Kiessling F, Talukder P, Mandl CW, Eppinger J, Chahal JS, Rueping M.   +8 more
europepmc   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

Effects of heterologous expression of glycolysis enzymes on product formation in <i>Clostridium thermocellum</i>. [PDF]

Metab Eng Commun
Chiarelli DP, Lynd LR, Bergamo LW, Olson DG.   +3 more
europepmc   +1 more source

An (αβ)2 Architecture of the Arabidopsis thaliana tRNA Splicing Endonuclease Complex: Structural Modeling and Evolutionary Analyses

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The tRNA splicing endonuclease (TSEN) removes introns from precursor tRNAs (pre‐tRNAs) in eukaryotes and archaea, but the architecture and subunit organization of plant TSEN remain poorly defined. Here, we integrated in planta bimolecular fluorescence complementation (BiFC) assays with AlphaFold3 (AF3)‐based structural modeling, molecular ...
Mohammad Moniruzzaman, Markus Englert, Kazuhito Akama   +2 more
wiley   +1 more source

Investigating the versatility of cytochalasan cytochrome P450 monooxygenases using combinatorial biosynthesis reveals stereochemical restrictions. [PDF]

Fungal Biol Biotechnol
Li L, Ali T, Goralczyk J, Jayasundara S, Paul A, de Amorim MR, Beemelmanns C, Skellam E.   +7 more
europepmc   +1 more source