Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll +7 more
wiley +2 more sources
Long-term immunity and protection against SARS-CoV-2 XBB.1.5 following homologous and heterologous mRNA and MVA vaccination. [PDF]
Pérez P +8 more
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Engineering the acid-tolerant yeast <i>Issatchenkia orientalis</i> for efficient lactic acid production via optimized glucose and xylose utilization. [PDF]
Lin Y, Kim A, Lee D, Kang NK.
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Differential functional immune recall across homologous and heterologous COVID-19 vaccination regimens. [PDF]
Che-Kamaruddin N +7 more
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HETEROLOGOUS AORTIC VALVE TRANSPLANTATION
J P, Binet +3 more
openaire +3 more sources
Ethical concerns regarding heterologous COVID-19 vaccine administration
Somsri Wiwanitkit, Viroj Wiwanitkit
doaj +1 more source
Tonoplast-Localized ABCC Transporters Enhance Heterologous Production of the Antidiabetic Montbretin A and Its Analogues in Nicotiana benthamiana. [PDF]
Hijmans C +4 more
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A new era in LSD control: Replacing goatpox vaccines with DIVA-enabled homologous strategies in India. [PDF]
Kumar N.
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Research progress on biosynthesis and regulation of monoterpenoid compounds. [PDF]
Zhang J +8 more
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Membrane-free bone regeneration using biphasic calcium phosphate, heterologous fibrin biopolymer, and photobiomodulation: an <i>in vivo</i> study. [PDF]
Pagani BT +9 more
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