Results 21 to 30 of about 280,719 (209)

Heterologous protein production in filamentous fungi

Applied Microbiology and Biotechnology, 2023
Filamentous fungi are able to produce a wide range of valuable proteins and enzymes for many industrial applications. Recent advances in fungal genomics and experimental technologies are rapidly changing the approaches for the development and use of ...
Dujuan Liu, S. Garrigues, R. D. de Vries
semanticscholar   +1 more source

Vaccine effectiveness of heterologous CoronaVac plus BNT162b2 in Brazil

Nature Medicine, 2022
There is considerable interest in the waning of effectiveness of coronavirus disease 2019 (COVID-19) vaccines and vaccine effectiveness (VE) of booster doses.
T. Cerqueira-Silva, S. Katikireddi, V. de Araujo Oliveira, Renzo Flores-Ortiz, J. B. Junior, E. Paixão, C. Robertson, G. Penna, G. Werneck, M. Barreto, N. Pearce, Aziz Sheikh, M. Barral-Netto, V. Boaventura   +13 more
semanticscholar   +1 more source

Pichia pastoris: A highly successful expression system for optimal synthesis of heterologous proteins

Journal of Cellular Physiology, 2020
One of the most important branches of genetic engineering is the expression of recombinant proteins using biological expression systems. Nowadays, different expression systems are used for the production of recombinant proteins including bacteria, yeasts,
M. Karbalaei, S. Rezaee, H. Farsiani
semanticscholar   +1 more source

Cellular immunity predominates over humoral immunity after homologous and heterologous mRNA and vector-based COVID-19 vaccine regimens in solid organ transplant recipients

American Journal of Transplantation, 2021
Knowledge on the immunogenicity of vector‐based and mRNA‐vaccines in solid organ transplant recipients is limited. Therefore, SARS‐CoV‐2–specific T cells and antibodies were analyzed in 40 transplant recipients and 70 controls after homologous or ...
T. Schmidt, V. Klemis, D. Schub, S. Schneitler, M. Reichert, H. Wilkens, U. Sester, M. Sester, J. Mihm   +8 more
semanticscholar   +1 more source

Evaluation of the Safety and Immunogenicity of Fractional Intradermal COVID-19 Vaccines as a Booster: A Pilot Study

Vaccines, 2022
Intradermal vaccination using fractional dosages of the standard vaccine dose is one strategy to improve access to COVID-19 immunization. We conducted a pilot study in healthy adults in Thailand to evaluate the safety and immunogenicity of intradermal ...
Suvimol Niyomnaitham, Somruedee Chatsiricharoenkul, Zheng Quan Toh, Sansnee Senawong, Chatkamol Pheerapanyawaranun, Supaporn Phumiamorn, Paul V. Licciardi, Kulkanya Chokephaibulkit   +7 more
doaj   +1 more source

Immunogenicity and Safety of Homologous and Heterologous Prime–Boost Immunization with COVID-19 Vaccine: Systematic Review and Meta-Analysis

Vaccines, 2022
A prime–boost strategy of COVID-19 vaccines brings hope to limit the spread of SARS-CoV-2, while the immunogenicity of the vaccines is waning over time. Whether a booster dose of vaccine is needed has become a widely controversial issue.
Haoyue Cheng, Zhicheng Peng, Shuting Si, Xialidan Alifu, Haibo Zhou, Peihan Chi, Yan Zhuang, Minjia Mo, Yunxian Yu   +8 more
doaj   +1 more source

Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil

Nature Communications, 2022
This study investigates the effectiveness of COVID-19 vaccine boosters following a primary series of CoronaVac vaccination. Using data from Brazil during the Omicron wave, the authors show that boosters provided protection against severe disease, with ...
O. Ranzani, M. Hitchings, R. L. de Melo, G. V. D. de França, Cássia de Fátima R. Fernandes, M. Lind, M. S. S. Torres, D. Tsuha, L. David, R. Said, M. Almiron, R. D. de Oliveira, D. Cummings, N. Dean, J. Andrews, A. Ko, J. Croda   +16 more
semanticscholar   +1 more source

The Pilot Study of Immunogenicity and Adverse Events of a COVID-19 Vaccine Regimen: Priming with Inactivated Whole SARS-CoV-2 Vaccine (CoronaVac) and Boosting with the Adenoviral Vector (ChAdOx1 nCoV-19) Vaccine

Vaccines, 2022
In response to the SARS-CoV-2 Delta variant, which partially escaped the vaccine-induced immunity provided by two doses of vaccination with CoronaVac (Sinovac), the National Vaccine Committee recommended the heterologous CoronaVac-ChAdOx1 (Oxford ...
Surakameth Mahasirimongkol, Athiwat Khunphon, Oraya Kwangsukstid, Sompong Sapsutthipas, Mingkwan Wichaidit, Archawin Rojanawiwat, Nuanjun Wichuckchinda, Wiroj Puangtubtim, Warangluk Pimpapai, Sakulrat Soonthorncharttrawat, Asawin Wanitchang, Anan Jongkaewwattana, Kanjana Srisutthisamphan, Daraka Phainupong, Naphatcha Thawong, Pundharika Piboonsiri, Waritta Sawaengdee, Thitiporn Somsaard, Kanokphon Ritthitham, Supaporn Chumpol, Nadthanan Pinyosukhee, Rattanawadee Wichajarn, Panadda Dhepakson, Sopon Iamsirithaworn, Supaporn Phumiamorn   +24 more
doaj   +1 more source

Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants

medRxiv, 2021
Background Heterologous prime-boost schedules with vector- and mRNA-based COVID-19 vaccines are already administered, but immunological responses and elicited protection have not been reported.
R. Gross, M. Zanoni, Alina Seidel, Carina Conzelmann, Andrea Gilg, Daniela Krnavek, Sümeyye Erdemci-Evin, Benjamin Mayer, M. Hoffmann, S. Pöhlmann, Alexandra Beil, J. Kroschel, B. Jahrsdörfer, H. Schrezenmeier, F. Kirchhoff, J. Münch, Janis A. Müller   +16 more
semanticscholar   +1 more source

Alloimmunity to Class 2 Human Leucocyte Antigens May Reduce HIV-1 Acquisition – A Nested Case-Control Study in HIV-1 Serodiscordant Couples

Frontiers in Immunology, 2022
Enveloped viruses, including the Human Immunodeficiency Virus-1 (HIV), incorporate host proteins such as human leucocyte antigens (HLA) into their envelope.
Melinda S. Suchard, Melinda S. Suchard, Neil Martinson, Neil Martinson, Susan Malfeld, Debbie de Assis Rosa, Romel D. Mackelprang, Romel D. Mackelprang, Jairam Lingappa, Jairam Lingappa, Xuanlin Hou, Helen Rees, Sinead Delany-Moretlwe, Hadassa Goldfein, Heena Ranchod, Heena Ranchod, David Coetzee, Kennedy Otwombe, Kennedy Otwombe, Lynn Morris, Lynn Morris, Caroline T. Tiemessen, Caroline T. Tiemessen, Dana M. Savulescu   +23 more
doaj   +1 more source