Results 61 to 70 of about 196,489 (314)
ON HETEROLOGOUS STRUMA OF THE KIDNEYS [PDF]
The American Journal of the Medical Sciences, 1889 n ...
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A Microfluidic Multiplex Sorter for Strain Development
Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.A new multiplex method for high‐throughput screening of yeast strains based on glucoamylase production is presented. Droplets containing single mutant yeast cells are incubated for enzyme production. A sorting platform divides mutants by their high‐ and mid‐activity levels.
Chiara Leal‐Alves +6 more
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Advanced Science, EarlyView.ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu +15 more
wiley +1 more source
The Case for Exploiting Cross-Species Epitopes in Malaria Vaccine Design
Frontiers in Immunology, 2020 The infection dynamics between different species of Plasmodium that infect the same human host can both suppress and exacerbate disease. This could arise from inter-parasite interactions, such as competition, from immune regulation, or both.
Catherine J. Mitran +2 more
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Willingness of college students to receive COVID-19 heterologous vaccination in Taizhou, China
Human Vaccines & Immunotherapeutics, 2023 This study aimed to determine the willingness of college students to choose COVID-19 heterologous vaccination and its associated influencing factors in Taizhou, China. A population-based, self-administered online questionnaire was conducted from March 15
Hui Shao +6 more
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Experimental Biology and Medicine, 1980 AbstractHuman fibroblast interferon (HFIF) and human leukocyte interferon (HLIF) can protect mouse L-929 cells against the cytopathic effects of vesicular stomatitis virus (VSV), although HLIF is about 60 times and HFIF about 1200 times less active than mouse interferon (MIF).
Pierre DeSomer +4 more
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Inhibition of RNase to Attenuate Fungal‐Manipulated Rhizosphere Microbiome and Diseases
Advanced Science, EarlyView.Fusarium graminearum uses its virulence effector Fg12, a fungal RNase, to manipulate the host rhizosphere microbiome and promote infection. Guanosine monophosphate (GMP) blocks Fg12's RNase activity. This reveals a key pathogen‐microbiota interaction mechanism and proposes GMP as a targeted strategy to disarm this core fungal effector, offering a ...
Bo Yang +13 more
wiley +1 more source
A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules
Advanced Science, EarlyView.Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang +6 more
wiley +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Frontiers in ImmunologyHeterologous prime-boost has broken the protective immune response bottleneck of the COVID-19 vaccines. however, the underlying mechanisms have not been fully elucidated.
Yanli Song +10 more
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