Results 81 to 90 of about 196,489 (314)
Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials
Viruses, 2010 Currently, there are more than 30 million people infected with HIV-1 and thousands more are infected each day. Vaccination is the single most effective mechanism for prevention of viral disease, and after more than 25 years of research, one vaccine has ...
Julia L. Hurwitz +10 more
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Advanced Science, EarlyView.The CtrCBL1‐CtrCIPK6 module of trifoliate orange (Citrus trifoliata L.) phosphorylates CtrBBX32, triggering its protein degradation under cold conditions, thereby relieving CtrBBX32‐mediated transcriptional repression of CtrZAT10 and CtrSTP1. The consequent upregulation of CtrZAT10 further activates CtrSTP1 expression, which enhances hexose transport ...
Xiangming Shang +10 more
wiley +1 more source
Advanced Science, EarlyView.The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan +5 more
wiley +1 more source
Complement Fixation Tests with Homologous and Heterologous Types of Coxsackie Virus in Man [PDF]
, 1952 Lisbeth M. Kraft, Joseph L. Melnick
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Advanced Science, EarlyView.This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen +12 more
wiley +1 more source
The influence of BCG on vaccine responses – a systematic review
Expert Review of Vaccines, 2018 Introduction: Bacillus Calmette-Guérin (BCG) vaccine is one of the most widely used vaccines worldwide. In addition to providing protection against tuberculosis, it has non-specific (heterologous) immunomodulatory effects.
Petra Zimmermann, Nigel Curtis
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HETEROLOGOUS TRANSPLANTATION OF MAMMALIAN TUMORS [PDF]
, 1941 Harry S. N. Greene
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Advanced Science, EarlyView.A natural variation in soybean PM30, GmPM30‐HapT, confers greater salt tolerance than GmPM30‐HapC via stronger GmLEA1‐GmPM30‐GmLEC1 interactions. Pyramiding their elite haplotypes yields additive gains in salt tolerance and yield, establishing a novel workflow linking evolutionary genomics, molecular mechanisms, and breeding applications via the module
Shiyu Huang +13 more
wiley +1 more source
Immunogenicity and efficacy of DNA/MVA HIV vaccines in rhesus macaque models
Expert Review of Vaccines, 2017 Introduction: Despite 30 years of research on HIV, a vaccine to prevent infection and limit disease progression remains elusive. The RV144 trial showed moderate, but significant protection in humans and highlighted the contribution of antibody responses ...
Lynette Siv Chea, Rama Rao Amara
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EFFECTS OF LARGE INFUSIONS OF HETEROLOGOUS SERUM PROTEINS ON THE SERUM PROTEIN METABOLISM OF RABBITS [PDF]
, 1955 Frank J. Dixon, Paul H. Maurer
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