Results 91 to 100 of about 15,687,915 (207)
A systems and molecular analysis of G protein-mediated signalling [PDF]
The ability of cells to respond correctly to signals from their microenvironment is an essential prerequisite of life. Many external signals are detected through G protein-coupled receptor (GPCR) signalling pathways, which control all aspects of ...
Croft, Wayne D.
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G Proteins and GPCRs in C. elegans Development: A Story of Mutual Infidelity
Journal of Developmental Biology, 2018 Many vital processes during C. elegans development, especially the establishment and maintenance of cell polarity in embryogenesis, are controlled by complex signaling pathways.
Daniel Matúš, Simone Prömel
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Structural dynamics and pH‐regulated membrane binding of the TRAF2‐NC trimer
Protein Science, Volume 35, Issue 11, November 2026.Abstract Tumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key adaptor in TNF receptor‐signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor‐binding domains (TRAF2‐NC, residues 266–501).
Federica Cossu +9 more
wiley +1 more source
Ligand-induced dynamics of heterotrimeric G protein-coupled receptor-like kinase complexes.
PLoS ONE, 2017 BackgroundArabidopsis, 7-transmembrane Regulator of G signaling protein 1 (AtRGS1) modulates canonical G protein signaling by promoting the inactive state of heterotrimeric G protein complex on the plasma membrane.
Meral Tunc-Ozdemir, Alan M Jones
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Massive Sampling Strategy for Antibody–Antigen Targets in CAPRI Round 55 With MassiveFold
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1768-1776, November 2026.ABSTRACT Massive sampling with AlphaFold2 improves protein–protein complex predictions. This has been shown during the last CASP15‐CAPRI blind prediction round by the AFsample tool. However, more difficult targets including antibody–antigen binding remain challenging. CAPRI Round 55 consisted of three antibody–antigen targets and one heterotrimer.
Nessim Raouraoua +2 more
wiley +1 more source
Role of the V2R–βarrestin–Gβγ complex in promoting G protein translocation to endosomes
Communications BiologyClassically, G protein-coupled receptors (GPCRs) promote signaling at the plasma membrane through activation of heterotrimeric Gαβγ proteins, followed by the recruitment of GPCR kinases and βarrestin (βarr) to initiate receptor desensitization and ...
Badr Sokrat +13 more
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Aging Cell, Volume 25, Issue 11, November 2026.Integrated multi‐omics identifies STAT1 as a central regulator of retinal aging, linking oxidative stress, inflammation, and senescence at neuro‐glial interfaces. ABSTRACT Aging is the dominant risk factor for retinal neurodegeneration, yet the upstream regulators that coordinate senescence‐associated programs across retinal cell types remain ...
Yiran Fan +9 more
wiley +1 more source
Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease
Acta Physiologica, Volume 242, Issue 11, November 2026.ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley +1 more source
Heterotrimeric G-protein signaling and light response
, 2009 Almost all creatures have invented sophisticated mechanisms to adjust their developmental and metabolic processes to the changing light intensities in day and night.
Monika Schmoll +3 more
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Heterotrimeric G-protein signaling in plants
, 2012 G-protein signalling is a key mechanism of cells interaction with the environment. It has a great significance for the coordination of cell division and differentiation in animals, Fungi and Mycetozoa.
Šonka, Josef
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