Results 71 to 80 of about 15,687,915 (207)

AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK‐Mediated Mitophagy

Cell Proliferation, EarlyView.
Compromised alveolar socket healing following tooth extraction upon Aff4 knockout is caused by suppressed osteogenic capacity of orofacial mesenchymal stem cells, which results from defective AMPK‐mediated mitophagy. ABSTRACT Repair of maxillofacial bone defects presents significant clinical challenges.
Li Zhu, Shuo Chen, Guowen Luo, Tingyue Zhang, Hengyi Lin, Yiling Chen, Chenchen Zhou, Shujuan Zou   +7 more
wiley   +1 more source

Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution

, 2015
Agonist binding to G-protein-coupled receptors (GPCRs) triggers signal transduction cascades involving heterotrimeric G proteins as key players. A major obstacle for drug design is the limited knowledge of conformational changes upon agonist binding, the
Plückthun, Andreas, Hillenbrand, Matthias, Schori, Christian, Schöppe, Jendrik, Schöppe J, Plückthun A, Schori C, Hillenbrand M   +7 more
core   +1 more source

Data_Sheet_5_The Role of Heterotrimeric G-Protein Beta Subunits During Nodulation in Medicago truncatula Gaertn and Pisum sativum L..PDF

, 2022
Heterotrimeric G-proteins regulate plant growth and development as master regulators of signaling pathways. In legumes with indeterminate nodules (e.g., Medicago truncatula and Pisum sativum), the role of heterotrimeric G-proteins in symbiosis ...
Elena A. Dolgikh (6566924), Irina V. Leppyanen (11935469), Olga A. Pavlova (11935463), Aleksandra V. Dolgikh (11935466), Andrey D. Bovin (11935460)   +4 more
core   +1 more source

Heterotrimeric G proteins

Türk Biyokimya Dergisi, 2007
Heterotrimeric G proteins, commonly known as G proteins are members of the large GTPase superfamily that are conserved from bacteria to mammals. G proteins play an essential role in cellular signaling by coupling many cell surface receptors to effectors on the plasma membrane.
Kuecuekkaya, Bahire, Kan, Beki
openaire   +3 more sources

Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

Nature Communications, 2017
Heterotrimeric guanine-nucleotide-binding proteins (G proteins) act as molecular switches. Here the authors use NMR relaxation analyses, which reveal the dynamics of G protein alpha subunit binding to GDP on a microsecond timescale.
Yuki Toyama, Hanaho Kano, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Ichio Shimada   +5 more
doaj   +1 more source

Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response. [PDF]

J Biol Chem, 2016
The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be ...
Alvaro CG, Thorner J.
europepmc   +2 more sources

Structural and functional insights into rhodopsin‐like and secretin‐like GPCR–arrestin interactions and regulation

The FEBS Journal, EarlyView.
Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta, Annette G. Beck‐Sickinger   +1 more
wiley   +1 more source

Data_Sheet_1_The Role of Heterotrimeric G-Protein Beta Subunits During Nodulation in Medicago truncatula Gaertn and Pisum sativum L..PDF

, 2022
Heterotrimeric G-proteins regulate plant growth and development as master regulators of signaling pathways. In legumes with indeterminate nodules (e.g., Medicago truncatula and Pisum sativum), the role of heterotrimeric G-proteins in symbiosis ...
Elena A. Dolgikh (6566924), Irina V. Leppyanen (11935469), Olga A. Pavlova (11935463), Aleksandra V. Dolgikh (11935466), Andrey D. Bovin (11935460)   +4 more
core   +1 more source

In vivo assembly and large-scale purification of a GPCR - Gα fusion with Gβγ, and characterization of the active complex.

PLoS ONE, 2019
G protein coupled receptors (GPCRs) are central players in recognizing a variety of stimuli to mediate diverse cellular responses. This myriad of functions is accomplished by their modular interactions with downstream intracellular transducers, such as ...
Abhinav Kumar, Andreas Plückthun
doaj   +1 more source

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling

Molecular Microbiology, EarlyView.
Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley   +1 more source