Results 51 to 60 of about 15,687,915 (207)
GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins. [PDF]
PLoS Computational Biology, 2012 After extra-cellular stimulation of G-Protein Coupled Receptors (GPCRs), GDP/GTP exchange appears as the key, rate limiting step of the intracellular activation cycle of heterotrimeric G-proteins.
Maxime Louet +2 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley +1 more source
Heterotrimeric G proteins in C. elegans [PDF]
WormBook, 2006 Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, are able to transduce signals from membrane receptors to a wide variety of intracellular effectors. In this role, G proteins effectively function as dimers since the signal is communicated either by the G alpha subunit or the stable G betagamma complex.
Carol, Bastiani, Jane, Mendel
openaire +2 more sources
mBio, 2014 Pasteurella multocida toxin (PMT) induces atrophic rhinitis in animals, which is characterized by a degradation of nasal turbinate bones, indicating an effect of the toxin on bone cells such as osteoblasts and osteoclasts.
Julia Strack +5 more
doaj +1 more source
Source files for "Mapping the conformational landscape of the stimulatory heterotrimeric G protein"
, 2022 Source files for Figures 1F, 2, 3, 4, 6, 7, and 8 in the manuscript "Mapping the conformational landscape of the stimulatory heterotrimeric G protein", submitted to Nature Structural & Molecular ...
Shuya Kate Huang (14265539) +1 more
core +1 more source
Development of an antibody fragment that stabilizes GPCR/G-protein complexes
Nature Communications, 2018 The determination of high resolution structures of G protein coupled receptors (GPCRs) in complex with heterotrimeric G proteins is challenging. Here authors develop an antibody fragment, mAB16, which stabilizes GPCR/G-protein complexes and facilitates ...
Shoji Maeda +9 more
doaj +1 more source
Real-time visualization of heterotrimeric G protein Gq activation in living cells
BMC Biology, 2011 Background Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living ...
Manders Erik MM +6 more
doaj +1 more source
Gαi protein subunit: A step toward understanding its non-canonical mechanisms
Frontiers in Cell and Developmental Biology, 2022 The heterotrimeric G protein family plays essential roles during a varied array of cellular events; thus, its deregulation can seriously alter signaling events and the overall state of the cell. Heterotrimeric G-proteins have three subunits (α, β, γ) and
Soraya Villaseca +6 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Rare de novo variants in GNAO1 cause a severe neurodevelopmental disorder characterized by a heterogenous display of early onset epilepsy, movement abnormalities, and global developmental delay. More than 100 pathogenic variants in GNAO1 have been identified and categorized into four groups according to their protein features.
Maria Sáez González +12 more
wiley +1 more source
Barley orthologs of the rice heterotrimeric G protein γ-subunits.
, 2016 Barley orthologs of the rice heterotrimeric G protein γ-subunits.
Toni Wendt (3600356) +8 more
core +1 more source