Results 41 to 50 of about 15,687,915 (207)
The repertoire of heterotrimeric G proteins and RGS proteins in Ciona intestinalis. [PDF]
PLoS ONE, 2009 BACKGROUND:Heterotrimeric G proteins and regulators of G protein signaling (RGS) proteins are key downstream interacting partners in the G protein coupled receptor (GPCR) signaling pathway.
R Prasobh, Narayanan Manoj
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Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability.
PLoS ONE, 2014 Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence.
W David Hill +13 more
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, 2005 Structural and mechanistic view of signaling between 2 GTPases: Heterotrimeric G protein and ...
Ji-Eun. Oh (7952345)
core +3 more sources
Arabidopsis G‐protein interactome reveals connections to cell wall carbohydrates and morphogenesis
Molecular Systems Biology, 2011 The heterotrimeric G‐protein complex is minimally composed of Gα, Gβ, and Gγ subunits. In the classic scenario, the G‐protein complex is the nexus in signaling from the plasma membrane, where the heterotrimeric G‐protein associates with heptahelical G ...
Karsten Klopffleisch +35 more
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Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
G Protein-coupled Receptor (GPCR) Signaling via Heterotrimeric G Proteins from Endosomes* [PDF]
, 2015 Some G protein-coupled receptors (GPCRs), in addition to activating heterotrimeric G proteins in the plasma membrane, appear to elicit a "second wave" of G protein activation after ligand-induced internalization.
Tsvetanova, Nikoleta G +2 more
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Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis
Nature Communications, 2018 Gip1 sequesters heterotrimeric G proteins in the cytosolic pool which regulates G protein-coupled receptor signalling for eukaryotic chemotaxis. Here the authors provide the crystal structure of Gip1's G protein-binding region and show that mutations in ...
Takero Miyagawa +6 more
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Advanced Science, EarlyView.This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang +13 more
wiley +1 more source
A FRET-based biosensor for measuring Gα13 activation in single cells. [PDF]
PLoS ONE, 2018 Förster Resonance Energy Transfer (FRET) provides a way to directly observe the activation of heterotrimeric G-proteins by G-protein coupled receptors (GPCRs).
Marieke Mastop +7 more
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Innovative Approach Reveals How Receptors Control G Protein State Equilibria
Advanced Science, EarlyView.Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou +12 more
wiley +1 more source