Regulators of G protein signalling proteins in the human myometrium [PDF]
, 2009 The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Ladds, Graham +4 more
core +1 more source
GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages
Nature Communications, 2022 G-protein-signaling modulator 1 (GPSM1), an accessory protein which activates heterotrimeric G-protein signaling, exhibits a genetic association with type 2 diabetes.
Jing Yan +20 more
doaj +1 more source
Gγ and Gα Identity Dictate a G-Protein Heterotrimer Plasma Membrane Targeting
Cells, 2019 Heterotrimeric G-proteins along with G-protein-coupled receptors (GPCRs) regulate many biochemical functions by relaying the information from the plasma membrane to the inside of the cell. The lipid modifications of Gα and Gγ subunits, together
Paweł Mystek +4 more
doaj +1 more source
Plant Morphology of Heterotrimeric G Protein Mutants. [PDF]
Plant Cell Physiol, 2016 The heterotrimeric G protein complex, comprising Galpha, Gbeta and Ggamma subunits, is an evolutionarily conserved-signaling molecular machine that transmits signals from transmembrane receptors to downstream target proteins.
Urano D +5 more
europepmc +2 more sources
Glucose attenuation of auxin-mediated bimodality in lateral root formation is partly coupled by the heterotrimeric G protein complex. [PDF]
PLoS ONE, 2010 Auxin and glucose are both essential elements in normal root development. The heterotrimeric G protein complex in Arabidopsis thaliana, defined as containing alpha (AtGPA1), beta (AGB1), and gamma (AGG) subunits and a GTPase accelerating protein called ...
Katherine S Booker +3 more
doaj +1 more source
Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica.
PLoS Pathogens, 2012 Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative agent of amoebic ...
Dustin E Bosch +7 more
doaj +1 more source
Assembly and Trafficking of Heterotrimeric G Proteins [PDF]
Biochemistry, 2007 To be activated by cell surface G protein-coupled receptors, heterotrimeric G proteins must localize at the cytoplasmic surface of plasma membranes. Moreover, some G protein subunits are able to traffic reversibly from the plasma membrane to intracellular locations upon activation.
Yannick, Marrari +3 more
openaire +2 more sources
Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein. [PDF]
, 2011 Arabidopsis thaliana AtNUDT7 Nudix pyrophosphatase hydrolyzes NADH and ADP-ribose in vitro and is an important factor in the cellular response to diverse biotic and abiotic stresses.
Olejnik, Kamil +7 more
core +2 more sources
Characterization of the Arabidopsis Heterotrimeric G Protein [PDF]
Journal of Biological Chemistry, 2008 We have used fluorescence resonance energy transfer and co-immunoprecipitation to analyze the interactions among the alpha, beta, and gamma1 subunits of the Arabidopsis heterotrimeric G protein. Using cyan and yellow fluorescent protein fusion constructs, we show that overexpressed Ggamma1 localizes to protoplast membranes, but Gbeta exhibits membrane ...
Shiyu, Wang +2 more
openaire +2 more sources
Diversity of heterotrimeric G-protein γ subunits in plants
BMC Research Notes, 2012 Background Heterotrimeric G-proteins, consisting of three subunits Gα, Gβ and Gγ are present in most eukaryotes and mediate signaling in numerous biological processes.
Trusov Yuri +2 more
doaj +1 more source