Results 11 to 20 of about 15,687,915 (207)
Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein [PDF]
eLife, 2018 The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule ...
Javier García-Nafría +4 more
doaj +4 more sources
Accessory proteins for heterotrimeric G-proteins in the kidney [PDF]
Frontiers in Physiology, 2015 Heterotrimeric G-proteins play a fundamentally important role in regulating signal transduction pathways in the kidney. Accessory proteins are being identified as direct binding partners for heterotrimeric G-protein α or βγ subunits to promote more ...
Frank ePark
doaj +5 more sources
The role of inhibitory G proteins and regulators of G protein signalling in the in-vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]
Frontiers in Physiology, 2012 Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels.
Richard eAng +2 more
doaj +2 more sources
Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa [PDF]
BMC Evolutionary Biology, 2018 Background Heterotrimeric G proteins are fundamental signaling proteins composed of three subunits, Gα and a Gβγ dimer. The role of Gα as a molecular switch is critical for transmitting and amplifying intracellular signaling cascades initiated by an ...
A. D. Lokits +4 more
doaj +2 more sources
Heterotrimeric G Protein-Mediated Signaling Is Involved in Stress-Mediated Growth Inhibition in Arabidopsis thaliana. [PDF]
Int J Mol Sci, 2023 Heterotrimeric G protein-mediated signaling plays a vital role in physiological and developmental processes in eukaryotes. On the other hand, because of the absence of a G protein-coupled receptor and self-activating mechanism of the Gα subunit ...
Yang S, Jung S, Lee H.
europepmc +2 more sources
Heterotrimeric G proteins in heart disease
Canadian Journal of Physiology and Pharmacology, 2000 Guanine nucleotide binding proteins (G proteins) are largely grouped into three classes: heterotrimeric G proteins, ras-like or small molecular weight GTP binding proteins, and others like Gh.
Ichiro Kouchi +3 more
core +3 more sources
Regulation of heterotrimeric G protein signaling by lipid microdomains.
, 2007 Regulation of heterotrimeric G protein signaling by lipid ...
John A. Allen (2309494)
core +5 more sources
Characterization of Heterotrimeric G Protein γ4 Subunit in Rice. [PDF]
Int J Mol Sci, 2018 Heterotrimeric G proteins are the molecule switch that transmits information from external signals to intracellular target proteins in mammals and yeast cells. In higher plants, heterotrimeric G proteins regulate plant architecture.
Matsuta S +5 more
europepmc +2 more sources
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
eLife, 2020 Heterotrimeric G-proteins are signal transducers involved in mediating the action of many natural extracellular stimuli and many therapeutic agents.
Mikel Garcia-Marcos +5 more
doaj +1 more source