Results 31 to 40 of about 15,687,915 (207)

Molecular Approaches To Target GPCRs in Cancer Therapy

Pharmaceuticals, 2011
Hundreds of G protein coupled receptor (GPCR) isotypes integrate and coordinate the function of individual cells mediating signaling between different organs in our bodies.
Giulio Innamorati, Maria Teresa Valenti, Francesco Giovinazzo, Luca Dalle Carbonare, Claudio Bassi, Marco Parenti   +5 more
doaj   +1 more source

Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

eLife, 2021
It has become evident that activation of heterotrimeric G-proteins by cytoplasmic proteins that are not G-protein-coupled receptors (GPCRs) plays a role in physiology and disease.
Mikel Garcia-Marcos
doaj   +1 more source

Molecular Basis of NPY Recognition and Ligand Selectivity at the Neuropeptide Y5 Receptor

Angewandte Chemie, EarlyView.
Here, we present the first active structure of the neuropeptide Y5 receptor (NPY5R) in complex with its endogenous ligand NPY and the Gi1 protein. The cryo‐electron microscopy structure, validated by extensive mutagenesis studies, gives important insights into the molecular mechanisms underlying ligand binding and receptor activation.
Lisa Christin Peuker, Hongyu Wang, Kun Chen, Kristin Löbner, Karin Mörl, Simon Jonas Schwarz, Qiang Zhao, Beili Wu, Annette Gabriele Beck‐Sickinger   +8 more
wiley   +2 more sources

Activation of heterotrimeric G proteins by Smoothened [PDF]

Proceedings of the National Academy of Sciences, 2006
The mechanisms by which the activation of Smoothened (Smo), a protein essential to the actions of the Hedgehog family of secreted proteins, is translated into signals that converge on the Gli transcription factors are not fully understood.
Natalia A, Riobo, Berangere, Saucy, Cherisse, Dilizio, David R, Manning   +3 more
openaire   +2 more sources

Competing activities of heterotrimeric G proteins in Drosophila wing maturation. [PDF]

PLoS ONE, 2010
Drosophila genome encodes six alpha-subunits of heterotrimeric G proteins. The Galphas alpha-subunit is involved in the post-eclosion wing maturation, which consists of the epithelial-mesenchymal transition and cell death, accompanied by unfolding of the
Natalya Katanayeva, Damir Kopein, Reto Portmann, Daniel Hess, Vladimir L Katanaev   +4 more
doaj   +1 more source

From Living in Saltwater to a Scarcity of Salt and Water, and Then an Overabundance of Salt—The Biological Roller Coaster to Which the Renin–Angiotensin System Has Had to Adapt: An Editorial

Biomedicines, 2023
Angiotensin II (Ang II) is a hormone with much more complex actions than is typical for other agonists with heterotrimeric G protein-coupled receptors (GPCRs) [...]
György L. Nádasy, András Balla, Mária Szekeres   +2 more
doaj   +1 more source

Heterotrimeric G‐proteins: a short history [PDF]

British Journal of Pharmacology, 2006
Some 865 genes in man encode G‐protein‐coupled receptors (GPCRs). The heterotrimeric guanine nucleotide‐binding proteins (G‐proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of intracellular second messengers ...
Graeme, Milligan, Evi, Kostenis
openaire   +2 more sources

Functional Interplay Between Arabidopsis NADPH Oxidases and Heterotrimeric G Protein

Molecular Plant-Microbe Interactions, 2013
The plant NADPH oxidases produce reactive oxygen species (ROS) in response to pathogens that have diverse functions in different cellular contexts. Distinct phenotypic outcomes may derive from the interaction of NADPH oxidase-dependent ROS with other ...
Miguel Angel Torres, Jorge Morales, Clara Sánchez-Rodríguez, Antonio Molina, Jeffery L. Dangl   +4 more
doaj   +1 more source

G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers [PDF]

, 2020
G protein-coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and
Arang, Nadia, J. Silvio Gutkind, Nadia Arang, Gutkind, J   +3 more
core   +1 more source

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

eLife, 2019
One of the largest membrane protein families in eukaryotes are G protein-coupled receptors (GPCRs). GPCRs modulate cell physiology by activating diverse intracellular transducers, prominently heterotrimeric G proteins. The recent surge in structural data
Ching-Ju Tsai, Jacopo Marino, Ricardo Adaixo, Filip Pamula, Jonas Muehle, Shoji Maeda, Tilman Flock, Nicholas MI Taylor, Inayatulla Mohammed, Hugues Matile, Roger JP Dawson, Xavier Deupi, Henning Stahlberg, Gebhard Schertler   +13 more
doaj   +1 more source