Results 91 to 100 of about 373,349 (265)

Guiding practitioners through end of life care for people with dementia: The use of heuristics.

PLoS ONE, 2018
BackgroundEnd of life care (EOLC) for people with dementia can present a multitude of challenges and difficult decisions for practitioners. These challenges may include assessment and management of difficulties with eating and swallowing, responding to ...
Nathan Davies, Jill Manthorpe, Elizabeth L Sampson, Kethakie Lamahewa, Jane Wilcock, Rammya Mathew, Steve Iliffe   +6 more
doaj   +1 more source

USING HEURISTIC METHODS AND TECHNIQUES TO STIMULATE A COLLECTIVE CREATIVITY OF EMPLOYEES OF THE ENTERPRISE

Вісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2015
The article deals with the establishment and development of heuristic techniques of stimulating creative activity of enterprise personnel based on science achievements and experience analysis.
G. Lozova
doaj   +1 more source

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

Advanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang, Wenkai Wang, Zhenling Peng, Jianyi Yang   +3 more
wiley   +1 more source

Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations

Advanced Science, EarlyView.
Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa, Nahoko Kuroki, Hirotoshi Mori   +2 more
wiley   +1 more source

Nonabelian Cohen-Lenstra Heuristics over Function Fields

, 2017
Boston, Bush, and Hajir have developed heuristics, extending the Cohen-Lenstra heuristics, that conjecture the distribution of the Galois groups of the maximal unramified pro-p extensions of imaginary quadratic number fields for p an odd prime.
Boston, Nigel, Wood, Melanie Matchett
core   +1 more source

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, EarlyView.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

HEURISTICS OPTIMISATION OF NUMERICAL FUNCTIONS [PDF]

, 2006
The article presents an investigation of heuristic behaviour of search algorithms applied to numerical problems. The aim is to compare the abilities of Particle Swarm Optimisation, Differential Evolution and Free Search to adapt to variety of search ...
Penev, Kalin
core   +1 more source

Prompt Engineering Accelerates the Data‐Driven Discovery of Photocatalysts via an LLM‐Based Model Ensemble Strategy

Advanced Science, EarlyView.
This work establishes a pipeline that transforms fragmented literature into a structured database for graphitic carbon nitride photocatalyst discovery. A prompt‐engineered, cross‐model large language model ensemble automates high‐fidelity extraction, enabling interpretable machine learning to identify dominant performance descriptors. These data‐driven
Dianyuan Li, Xichen Sun, Shaohua Sun, Runzhou Wang, Miaomiao Zhang, Meng Xiao, Yue Wang, Yuezhou Zhang   +7 more
wiley   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source