Results 111 to 120 of about 481,157 (359)

Reference‐Guided Chromosome‐by‐Chromosome de novo Assembly at Scale Using Low‐Coverage High‐Fidelity Long‐Reads with HiFiCCL

open access: yesAdvanced Science, EarlyView.
HiFiCCL, as the first assembly framework specifically designed for low‐coverage high‐fidelity reads, improves the assembly quality of existing assemblers and also enhances downstream applications such as large structural variant (SV) detection (>10 000 bp), synteny analysis, pangenome graph construction, and graph‐based individual‐specific germline SVs
Zhongjun Jiang   +9 more
wiley   +1 more source

Quantitative Assessment of Randomized DNA Base Sequences Using Multi‐Model Physical Analysis for High‐Fidelity Data Storage

open access: yesAdvanced Science, EarlyView.
This study quantitatively evaluates randomized DNA sequence design for digital data storage using three physics‐based models. By applying encoding schemes with strict homopolymer constraints, the framework improves base randomness, GC balance, and error resilience. Experimental validation via PCR and Sanger sequencing confirms 95–98% decoding accuracy,
Seongjun Seo   +6 more
wiley   +1 more source

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

open access: yesAdvanced Science, EarlyView.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan   +9 more
wiley   +1 more source

Unveiling the Formation and Evolution of the Cathode–Electrolyte Interphase in Lithium–Sulfur Batteries

open access: yesAdvanced Science, EarlyView.
By integrating electrochemical impedance spectroscopy (EIS), background‐subtracted in situ Fourier‐transform infrared (FTIR) spectroscopy, and X‐ray absorption spectroscopy (XAS), this work reveals electrolyte decomposition and the reduced species involved in forming the cathode–electrolyte interphase (CEI) in lithium–sulfur batteries (LSBs), offering ...
Murilo Machado Amaral   +9 more
wiley   +1 more source

Some heuristics about elliptic curves [PDF]

open access: yes, 2006
We give some heuristics for counting elliptic curves with certain properties. In particular, we re-derive the Brumer-McGuinness heuristic for the number of curves with positive/negative discriminant up to $X$, which is an application of lattice-point ...
Watkins, Mark
core   +2 more sources

How simple rules determine pedestrian behavior and crowd disasters

open access: yes, 2011
With the increasing size and frequency of mass events, the study of crowd disasters and the simulation of pedestrian flows have become important research areas. Yet, even successful modeling approaches such as those inspired by Newtonian force models are
Barab  si   +15 more
core   +2 more sources

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

open access: yesAdvanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang   +3 more
wiley   +1 more source

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