Results 31 to 40 of about 1,761 (159)

A High Throughput Substrate Binding Assay Reveals Hexachlorophene as an Inhibitor of the ER-resident HSP70 Chaperone GRP78 [PDF]

, 2019
Glucose-regulated protein 78 (GRP78) is the ER resident 70 kDa heat shock protein 70 (HSP70) and has been hypothesized to be a therapeutic target for various forms of cancer due to its role in mitigating proteotoxic stress in the ER, its elevated ...
Johnson, Steven M., Chapman, Eli, Schmidlin, Cody J., Shi, Taoda, Ross, Alison B., Zhang, Donna D., Sivinski, Jared, Widrick, Kimberly J., Ambrose, Andrew J., Zerio, Christopher J.   +9 more
core   +1 more source

Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes

Frontiers in Endocrinology, 2013
We recently found evidence for anatomic and physical linkages between the astroglial Na+-dependent glutamate transporters (GLT-1/EAAT2 and GLAST/EAAT1) and mitochondria.
Brendan S Whitelaw, Michael B Robinson, Michael B Robinson, Michael B Robinson   +3 more
doaj   +1 more source

Chemie und Pharmazie in die Nachhaltigkeit einbetten

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Chemie und Pharmazie sind mit ihren Produkten und Prozessen grundlegend für unseren hohen Lebensstandard. Es ist wesentlich, ihre Verbindung mit der Nachhaltigkeit zu verstehen, damit sie auf nachhaltige Weise nachhaltig zur Nachhaltigkeit beitragen können.
Klaus Kümmerer
wiley   +1 more source

Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells [PDF]

, 2018
International audienceThe hexachlorophene (HCP) is a highly lipophilic chlorinated bisphenol present in hygienic and dermatological products. The HCP accumulates preferentially in adipose tissue that is a privileged source of mesenchymal stem cells (MSCs)
Lewicki, Slawomir, Suska, Milena, Brewczynska, Aleksandra, Lesniak, Monika, Wanda Stankiewicz, Sławomir Lewicki, Kubiak, Jacek Z., Zdanowski, Robert, Monika Leśniak, Jacek Z Kubiak, Aleksandra Brewczyńska, Milena Suska, Stankiewicz, Wanda, Małgorzata Kloc, Robert Zdanowski, Kloc, Malgorzata   +15 more
core   +1 more source

Embedding Chemistry and Pharmacy Into Sustainability

Angewandte Chemie International Edition, Volume 65, Issue 29, 13 July 2026.
Chemistry and pharmacy provide products and processes that are indispensable for our high living standard. To understand their relationship with sustainability is important to allow them to contribute to sustainability in a sustainable manner. An integrated overview of green, circular, and sustainable chemistry and pharmacy is given and how they have t
Klaus Kümmerer
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Identifying Gene Predictors of Chemicals Linked With Breast Cancer: A Machine Learning Analysis of MCF7 Cellular Transcriptomic Screening Data

Environmental and Molecular Mutagenesis, Volume 66, Issue 8, Page 425-441, October 2025.
ABSTRACT Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing data from human breast cancer‐derived MCF7 cells exposed to hundreds of individual chemicals.
Lauren E. Koval, Richard Judson, Julia E. Rager   +2 more
wiley   +1 more source

MS [PDF]

, 2007
thesisThe purpose of this study was to evaluate the effectiveness of Foamaseptic, a non-hexachlorophene soap product, against gram-positive and gram-negative organisms as found on the hands of the nursing personnel of the Newborn Intensive Care Unit of ...
Vasquez, Elizabeth F.
core  

Pruritus and Its Association With Cancer and Mortality in Dermatomyositis and Polymyositis: A Nationwide Cohort Study in Taiwan From 2005 to 2022

Dermatologic Therapy, Volume 2025, Issue 1, 2025.
Background: Pruritus is the most common initial symptom reported by patients with dermatomyositis (DM) and polymyositis (PM). However, there is limited data regarding the impact of pruritus on cancer and mortality in patients with DM and PM. In this study, we aimed to investigate how pruritus is associated with cancer and mortality in patients with DM ...
Der-Jr Huang, Yu-Hsuan Joni Shao, Yi-Hsien Shih, Woan-Ruoh Lee, Ling-Ya Huang, Yu-Min Kuo, Quoc Thao Trang Pham, Hao-Jui Weng, Suraiya Saleem   +8 more
wiley   +1 more source

Effect of hexachlorophene and benzalkonium chloride on the capability of SmeT to bind its operator DNA.

, 2015
A γ-[32P] labeled double stranded DNA fragment containing the SmeT operator site (lane 1) was incubated with SmeT (0.2 μM) for 20 min at room temperature (lane 2).
Carlo Viti (177838), Marco Rinaldo Oggioni (177840), Francesca Decorosi (177830), José Luis Martínez (434696), María Blanca Sánchez (774077), Alvaro Hernández (5652970)   +5 more
core   +1 more source