Results 41 to 50 of about 1,761 (159)

Genome‐Wide Association Studies Data and Transcriptomics Data Link Herpes Simplex Virus 1 Infection and Parkinson’s Disease

open access: yesParkinson's Disease, Volume 2025, Issue 1, 2025.
Objective The main goal of this study is to explore the link between herpes simplex virus 1 (HSV‐1) infection and Parkinson’s disease (PD) from the genome‐wide association studies (GWAS) data and find the shared molecular signature for mechanism understanding and drug repurposing from the transcriptomics data.
Changhao Lu   +6 more
wiley   +1 more source

Advancing Anticancer Drug Discovery: Leveraging Metabolomics and Machine Learning for Mode of Action Prediction by Pattern Recognition

open access: yesAdvanced Science, Volume 11, Issue 47, December 18, 2024.
This study explores the integration of metabolomics with machine learning to predict the mode of action (MoA) of anti‐proliferative drugs in cancer cells. Complex metabolite patterns of drug‐treated cells are trained by machine learning to classify the drug's MoA.
Mohamad Saoud   +12 more
wiley   +1 more source

Photopatch testing: Clinical characteristics, test results, and final diagnoses from the North American Contact Dermatitis Group, 2009–2020

open access: yesContact Dermatitis, Volume 91, Issue 6, Page 465-473, December 2024.
Among 454 North American patients referred for photopatch testing between 2009 and 2020, nearly 20% were diagnosed with photoallergic contact dermatitis. Sunscreens, particularly benzophenones, were by far the most common photoallergens (almost 90% of positive photopatch tests).
Vincent A. DeLeo   +17 more
wiley   +1 more source

A note on the determination of dichlorophen and hexachlorophene in mixtures

open access: yes, 1970
Dichlorophen and hexachlorophene can be separated and estimated rapidly. Separation was achieved on thin-layer chromatograms using ethyl acetate containing 10% v/v of methanol and silica gel, the appropriate areas for each compound being collected and ...
R W Daisley, C J Olliff
core   +1 more source

Surprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen

open access: yesContact Dermatitis, Volume 91, Issue 6, Page 474-484, December 2024.
Ketoprofen‐containing gels, available in Sweden in the early 2000. Photo courtesy of the Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö. Abstract Objective Photoallergic reactions due to topical ketoprofen are common.
V. Marmgren   +4 more
wiley   +1 more source

In silico approach to identify the potential targets of Alexidine dihydrochloride and Hexachlorophene in human fungal pathogen C. glabrata

open access: yesEnvironment Conservation Journal
Widespread usage of antifungals has led to the development of antifungal resistance, causing a change in the epidemiology of the responsible agents from albicans to non-Candida albicans species.
Ayesha Ansari   +3 more
doaj   +1 more source

Single‐cell sequencing combined with transcriptomics and in vivo and in vitro analysis reveals the landscape of ferroptosis in myocardial ischemia–reperfusion injury

open access: yesThe FASEB Journal, Volume 38, Issue 21, 15 November 2024.
Key genes influencing cardiomyocyte ferroptosis in myocardial ischemia–reperfusion were identified using single‐cell sequencing data. These genes were further validated through transcriptomic data analysis and immune infiltration assessments. Subsequent investigations included analyzing the motifs regulating these key genes, predicting potential ...
Chongning Zhong   +5 more
wiley   +1 more source

What is the role of current mass spectrometry in pharmaceutical analysis?

open access: yesMass Spectrometry Reviews, Volume 43, Issue 3, Page 560-609, May/June 2024.
Abstract The role of mass spectrometry (MS) has become more important in most application domains in recent years. Pharmaceutical analysis is specific due to its stringent regulation procedures, the need for good laboratory/manufacturing practices, and a large number of routine quality control analyses to be carried out.
Maria Khalikova   +5 more
wiley   +1 more source

THE MODE OF ACTION OF CHLORINATED BISPHENOL ANTIBACTERIALS: Part I. Metal Chelates of Hexachlorophene and Thiobisdichlorphenol

open access: yes, 1958
2:2′-Thiobis(4:6-dichlorphenol) has been found to chelate with Fe++, Fe+++, Cu++, Mn++ and Co++ as shown by colorimetric, Potentiometrie and analytical data.
J B Adams
core   +1 more source

Functional promiscuity of small multidrug resistance transporters from Staphylococcus aureus, Pseudomonas aeruginosa, and Francisella tularensis

open access: yesMolecular Microbiology, Volume 121, Issue 4, Page 798-813, April 2024.
Three SMRs from high‐priority pathogens were heterologously expressed in Escherichia coli and compared to transport‐dead mutants. A broad screen revealed that these transporters can confer both resistance and susceptibility to many compounds, consistent with the behavior of the model SMR EmrE.
Peyton J. Spreacker   +6 more
wiley   +1 more source

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