The FASEB Journal, Volume 40, Issue 7, 15 April 2026.We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala +3 more
wiley +1 more source
BRG1 orchestrates diabetic corneal neuropathy via PI3K/AKT-mediated glycolytic reprogramming. [PDF]
Eye Vis (Lond)Deng Y, Chen W, Liao D, Hu J.
europepmc +1 more source
Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation [PDF]
, 2018 Fanxin Long +5 more
core +2 more sources
Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke. [PDF]
J NeuroinflammationWon SJ +13 more
europepmc +1 more source
Substrate Specificity of Hexokinases
Journal of Biological Chemistry, 1961 C F, LANGE, P, KOHN
openaire +2 more sources
p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells. [PDF]
ElifeKumar R +14 more
europepmc +1 more source
Un-sweetening the deal: targeting glucose metabolism in brain arteriovenous malformations. [PDF]
EMBO Mol MedRudnicki M, Haas TL.
europepmc +1 more source
HEXOKINASES OF SCHISTOSOMA MANSONI
Journal of Biological Chemistry, 1955 E, BUEDING, J A, MACKINNON
openaire +2 more sources
Re-Evaluating the Treatment Plan for Diabetic Macular Edema Based on Early Identification of Response and Possible Biochemical Predictors of Non-Response After the First Intravitreal Ranibizumab Injection. [PDF]
BiomedicinesElgouhary SM +6 more
europepmc +1 more source
Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance. [PDF]
Nat CommunZhu Q +15 more
europepmc +1 more source