Results 81 to 90 of about 810 (162)

Development of Methods to Produce SARS CoV‐2 Virus‐Like Particles at Scale

Biotechnology and Bioengineering, Volume 122, Issue 5, Page 1118-1129, May 2025.
ABSTRACT The devastating global toll precipitated by the SARS CoV‐2 outbreak and the profound impact of vaccines in stemming that outbreak has established the need for molecular platforms capable of rapidly delivering effective, safe and accessible medical interventions in pandemic preparedness.
Melissa A. Edeling, Linda Earnest, Julio Carrera Montoya, Ashley Huey Yiing Yap, Jamie Mumford, Jason Roberts, Chinn Yi Wong, Dhiraj Hans, Joseph Grima, Nicole Bisset, Jesse Bodle, Steven Rockman, Joseph Torresi   +12 more
wiley   +1 more source

Intracellular trafficking of adenovirus protein II (Hexon) and its significance with respect to design of non-viral Gene delivery system

, 2017
A successful non-viral gene delivery system needs to accomplish its tasks by delivering the therapeutic gene to the nucleus of the targeted cell. To do so, the system needs to cross the cell membrane, travels towards the nuclear pore complex, and enters ...
Hsieh, Ming Je (3718948)
core   +1 more source

Whole Genome Sequencing and Genetic Diversity of Respiratory Viruses Detected in Children With Acute Respiratory Infections: A One‐Year Cross‐Sectional Study in Senegal

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT Acute respiratory infections (ARI) are a health priority, especially in countries with limited resources. They are a major cause of morbidity and mortality, especially among children and the elderly. In Senegal, the endemic circulation of respiratory viruses other than influenza has been demonstrated.
Anna Julienne Selbé Ndiaye, Sebastien Cortaderona, Léa Delorme, Mamadou Beye, Idir Kacel, Vincent Bossi, Gora Lo, Nafissatou Leye, Abdou Padane, Halimatou Diop‐Ndiaye, Coumba Touré Kane, Ndèye Ramatoulaye Diagne, Cheikh Sokhna, Souleymane Mboup, Pierre‐Edouard Fournier   +14 more
wiley   +1 more source

Human full-length coagulation factor X and a GLA domain-derived 40-mer polypeptide bind to different regions of the adenovirus serotype 5 hexon capsomer [PDF]

, 2014
The interaction of HAdV-C5 and many other adenoviruses with blood coagulation factors (e.g. human factor X; FX) involves the binding of their GLA domain to the hexon capsomers, resulting in high levels of hepatotropism and potential hepatotoxicity.
Sumarheni, Sumarheni
core  

Evaluation of Lytic and Persistent Human Adenovirus Infections in Tonsil Tissue of Children With Tonsillar Hypertrophy: A Matched Case–Control Study

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 2, April 2025.
This study investigated the role of human adenoviruses (HAdVs) in tonsillar hypertrophy among children by analyzing oropharyngeal swabs and tonsillar tissues from 50 children. HAdV‐C genomes were detected in 32% of hypertrophic tissues, with a predominance of persistent infections (81%) and varying viral loads that peaked in children under 5 years of ...
Zahra Heydarifard, Sevrin Zadheidar, Shirin Kalantari, Ahmad Nejati, Farshid Achak, Vahid Salimi, Talat Mokhtari‐Azad, Nazanin Zahra Shafiei‐Jandaghi   +7 more
wiley   +1 more source

Phylogenetic analysis of the human adenovirus type 3 and type 7 hexon and fiber genes.

, 2015
The phylogenetic tree was inferred from HAdV-7 hexon gene (A), HAdV-7 fiber gene (B), HAdV-3 hexon gene (C) and HAdV-3 fiber gene (D). Tree topology was constructed using the neighbor-joining method.
Po-Liang Lu (5309), Yung-Cheng Lin (209958), Pei-Yu Chu (456124), Jih-Hui Lin (209948), Kuei-Hsiang Lin (198416), Chu-Feng Wang (740633), Hsin-Fu Liu (209960)   +6 more
core   +1 more source

Novel Genotype Definition and the First Epidemiological Investigation of Canine Adenovirus Type 2 in Dogs in Central China

Frontiers in Veterinary Science, 2020
Infections caused by canine adenovirus (CAdV) type 1 have been reported worldwide in the past two decades. However, only few studies have specifically reported the prevalence of CAdV type 2 (CAdV-2).
Jun Ji, Wanyu Li, Wen Hu, Xin Xu, Yunchao Kan, Lunguang Yao, Yingzuo Bi, Qingmei Xie   +7 more
doaj   +1 more source

Proteomic Analysis of Marine Bacteriophages: Structural Conservation, Post‐Translational Modifications, and Phage–Host Interactions

Environmental Microbiology, Volume 27, Issue 4, April 2025.
This study used proteomics to determine the relative abundance of proteins in 13 marine phages, constructing detailed phage architecture models. Protein structure comparisons revealed evolutionary traits, while identified post‐translational modifications (PTMs) suggest that phages utilise PTMs to evade host immune defences, providing new insights into ...
Shuzhen Wei, Anan Wang, Lanlan Cai, Ruijie Ma, Longfei Lu, Jiangtao Li, Rui Zhang   +6 more
wiley   +1 more source

Sequencing and comparative analysis of hexon gene of fowl adenovirus 4 of Indian origin

, 2005
367-372The sequencing of the recombinant plasmid containing 2916 bp hexon gene insert of fowl adeno virus 4 (FAV4) of Indian origin revealed the complete nucleotide sequence of the FAV4 hexon gene.
Bandyopadhyay, S K, Rai, A, Mondal, B, Hemadri, D, Sanyal, A, Barua, S   +5 more
core  

Human adenovirus serotype 5 infection dysregulates cysteine, purine, and unsaturated fatty acid metabolism in fibroblasts

The FASEB Journal, Volume 39, Issue 5, 15 March 2025.
Human adenovirus serotype 5 was used to infect HEK293 fibroblasts at low MOI (0.5, 1.0, and 2.0). Infected cells were interrogated by gas chromatography time‐of‐flight mass spectrometry (GC‐TOF‐MS) at 6, 12, 24, and 36 h post‐infection. The total metabolites were evaluated using an untargeted analysis of primary carbons. The results indicate a decrease
Bailey‐J C. Sanchez, Rudy M. Ortiz, Juris A. Grasis   +2 more
wiley   +1 more source