Results 21 to 30 of about 7,225 (221)

Síntese de inibidores potenciais de hexosaminidases derivados de N-acetilglicosamina e D-glicose

Orbital: The Electronic Journal of Chemistry, 2012
We report herein the synthesis and characterization of N-acetylglucosamine and D-glucose derivates modified at C-1 for evaluation of antifungal activity as potential hexosaminidases inhibitors.
Lucas Lopardi Franco, Mário C. Brandão, Ricardo José Alves, José Dias Souza Filho   +3 more
doaj   +1 more source

Isolation and relationship of human hexosaminidases.

Journal of Biological Chemistry, 1974
A method for the preparation of highly purified β-hexosaminidase isozymes A and B from human placenta is presented. The purified enzymes possess identical molecular weight and exhibit similar kinetic parameters with artificial fluorogenic substrates.
J. Tallman, R. Brady, J. Quirk, M. Villalba, A. E. Gal   +4 more
semanticscholar   +3 more sources

Induced secretion of β-hexosaminidase by human brain endothelial cells: A novel approach in Sandhoff disease?

Neurobiology of Disease, 2010
Sandhoff disease is an autosomal recessive lysosomal disorder due to mutations in the β-hexosaminidase β-chain gene, resulting in β-hexosaminidases A (αβ) and B (ββ) deficiency and GM2 ganglioside accumulation in the brain.
Lionel Batista, Florence Miller, Céline Clave, Audrey Arfi, Gaëlle Douillard-Guilloux, Pierre-Olivier Couraud, Catherine Caillaud   +6 more
doaj   +1 more source

Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. [PDF]

PLoS Genetics, 2014
As newly synthesized glycoproteins move through the secretory pathway, the asparagine-linked glycan (N-glycan) undergoes extensive modifications involving the sequential removal and addition of sugar residues.
Erica E Rosenbaum, Eva Vasiljevic, Kimberley S Brehm, Nansi Jo Colley   +3 more
doaj   +1 more source

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate [PDF]

, 2001
Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques(1). A catalytic mechanism, featuring a long-lived oxo-carbenium-ion intermediate, was proposed on the basis of model ...
A Federov, AL Fink, AT Brünger, BA Malcolm, BL Mark, CC Blake, Collaborative Computational Project Number 4, DC Phillips, DE Koshland, DM Chipman, E Holler, FW Ballardie, FW Dahlquist, G Sulzenbacher, GJ Davies, GJ Davies, GN Murshodov, I Matsumura, I Tews, ML Sinnott, NCJ Strynadka, Q Wang, R Kuroki, S Rosenberg, T Rand-Meir, TL Amyes, V Notenboom, WP Burmeister, Z Otwinowski   +28 more
core   +1 more source

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Molecules, 2018
From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors
Patrick Weber, Seyed A. Nasseri, Bettina M. Pabst, Ana Torvisco, Philipp Müller, Eduard Paschke, Marion Tschernutter, Werner Windischhofer, Stephen G. Withers, Tanja M. Wrodnigg, Arnold E. Stütz   +10 more
doaj   +1 more source

Novel transmembrane receptor involved in phagosome transport of lysozymes and β-hexosaminidase in the enteric protozoan Entamoeba histolytica. [PDF]

PLoS Pathogens, 2012
Lysozymes and hexosaminidases are ubiquitous hydrolases in bacteria and eukaryotes. In phagocytic lower eukaryotes and professional phagocytes from higher eukaryotes, they are involved in the degradation of ingested bacteria in phagosomes.
Atsushi Furukawa, Kumiko Nakada-Tsukui, Tomoyoshi Nozaki   +2 more
doaj   +1 more source

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry [PDF]

, 2018
The attachment of the sugar N-acetyl-D-glucosamine (GlcNAc) to specific serine and threonine residues on proteins is referred to as protein O-GlcNAcylation.
Aristotelous, Tonia, Borodkin, Vladimir S., Ferenbach, Andrew T., Navratilova, Iva, Rafie, Karim, Selvan, Nithya, Van Aalten, Daan M.F.   +6 more
core   +3 more sources

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human : O-GlcNAcase [PDF]

, 2016
The modification of nucleocytoplasmic proteins with O-linked N-Acetylglucosamine (O-GlcNAc) plays diverse roles in multicellular organisms. Inhibitors of O-GlcNAc hydrolase (OGA), the enzyme that removes O-GlcNAc from proteins, lead to increased O-GlcNAc
Avalos Gonzalez, Bartlett, Beer, Borghgraef, Cetinbas, Copeland, Dennis, Dorfmueller, Dorfmueller, Dorfmueller, Ferrer, Gao, Graham, Greig, Haltiwanger, Hart, Khidekel, Kim, Kim, Kreppel, Kuntz, Kuzmic, Liu, Liu, Lombard, Lubas, Ma, Macauley, Macauley, Macauley, Macauley, Macauley, Mader, Mark, Mehdy, Morrison, Mosi, Murphy, Ortiz-Meoz, Ozcan, Perrin, Ranuncolo, Rao, Roeser, Ruan, Stubbs, Torres, Trinidad, Wang, Whelan, Whitworth, Yi, Yuzwa, Yuzwa, Yuzwa, Yuzwa, Zhu   +56 more
core   +1 more source

OGA Inhibition By GlcNAc-Selenazoline [PDF]

, 2010
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay.
Abdo, M., Darout, E., Hanover, J. A., Kim, E. J., Knapp, S., Love, D. C., Rablen, Paul R., Rempel, B., Withers, S. G.   +8 more
core   +2 more sources