Results 81 to 90 of about 7,225 (221)

GlcNAcstatin:a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels [PDF]

, 2006
Many phosphorylation signal transduction pathways in the eukaryotic cell are modulated by posttranslational modification of specific serines/threonines with N-acetylglucosamine (O-GlcNAc).
Borodkin, Vladimir S., Dorfmueller, Helge C., Schimpl, Marianne, Shepherd, Sharon M., Shpiro, Natalia A., van Aalten, Daan M. F.   +5 more
core   +3 more sources

Molecular and Biochemical Characterization of a Novel β-N-Acetyl-D-Hexosaminidase with Broad Substrate-Spectrum from the Aisan Corn Borer, Ostrinia Furnacalis

International Journal of Biological Sciences, 2012
Insect β-N-acetyl-D-hexosaminidases with broad substrate-spectrum (IBS-Hex) are the homologues of human β-N-acetyl-D-hexosaminidase A/B (HsHex A/ B). These enzymes are distributed in most insect species and vary in physiological roles.
Fengyi Liu, Tian Liu, Mingbo Qu, Qing Yang
doaj  

Enhancement of lysosomal glycohydrolase activity in human primary B lymphocytes during spontaneous apoptosis. [PDF]

, 2007
It has been shown that lysosomes are involved in B cell apoptosis but lysosomal glycohydrolases have never been investigated during this event. In this study we determined the enzymatic activities of some lysosomal glycohydrolases in human tonsil B ...
A. Frenguelli, A. Orlacchio, Alessandro Magini, C. Tassi, Carla Emiliani, Emanuela Rosati, Pierfrancesco Marconi, Rita Sabatini, S. Mencarelli, Stefano Coaccioli   +9 more
core   +2 more sources

A Study of Abscisic Acid Regulated Enzymes and Histone Binding Proteins in Plants [PDF]

, 2015
Plant hormone abscisic acid (ABA) plays a main role in coordinating various stress signals in plants. ABA regulates the expression of genes and activities of enzymes in response to various stress conditions. In the following studies we were able to study
Kolli, Udhghatri
core   +1 more source

Enzymatic Hydrolysis of Human Milk Oligosaccharides. The Molecular Mechanism of Bifidobacterium Bifidum Lacto-N-biosidase [PDF]

Bifidobacterium bifidum lacto-N-biosidase (LnbB) is a critical enzyme for the degradation of human milk oligosaccharides in the gut microbiota of breast-fed infants.
Biarnés, Xevi, Coines, Joan, Cuxart, Irene, Esquivias, Oriol, Faijes, Magda, Planas, Antoni, Rovira i Virgili, Carme   +6 more
core   +1 more source

Increased trans-glycosylation activity of hexosaminidases for synthesis of human milk oligosaccharides [PDF]

, 2017
It is well known that the composition of human breast milk differs significantly from the one of ordinary bovine milk. Especially the presence of sialylated and fucosylated oligosaccharides contributes to its health and development promoting features for
Busk, Peter K., Holck, Jesper, Jamek,, Shariza B., Lange, Lene, Meyer, Anne S., Mikkelsen, Jørn D., Muschiol, Jan   +6 more
core   +1 more source

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

Chemistry and Biology, 2010
H. Dorfmueller, V. Borodkin, M. Schimpl, Xiaowei Zheng, Robert Kime, K. Read, D. V. van Aalten   +6 more
semanticscholar   +1 more source

Bioinformatic, enzymatic and structural characterization ofTrichuris suishexosaminidase HEX-2

, 2023
Dutkiewicz Z, Varrot A, Breese KJ, Stubbs KA, Nuschy L, Adduci I, Paschinger K, Wilson IBH.   +7 more
europepmc   +1 more source

A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.

Angewandte Chemie, 2009
K. Stubbs, Matthew S Macauley, D. Vocadlo   +2 more
semanticscholar   +1 more source

Purification and properties of human kidney-cortex hexosaminidases A and B.

Biochemical Journal, 1977
J. Wiktorowicz, Y. Awasthi, A. Kurosky, S. Srivastava   +3 more
semanticscholar   +1 more source