Results 21 to 30 of about 1,451 (118)

Local frustration around enzyme active sites [PDF]

, 2019
Conflicting biological goals often meet in the specification of protein sequences for structure and function. Overall, strong energetic conflicts are minimized in folded native states according to the principle of minimal frustration, so that a sequence ...
Ferreiro, Diego, Freiberger, Maria Ines, Guzovsky, Ana Brenda, Parra, Rodrigo Gonzalo, Wolynes, Peter G.   +4 more
core   +1 more source

Proteomic and metabolic disturbances in lignin-modified Brachypodium distachyon [PDF]

, 2022
This article investigates global metabolic responses to lignin pathway perturbations in the model grass Brachypodium distachyon using a systems biology ...
Abraham, Paul E., Barros, Jaime, Dixon, R. A., Engle, Nancy L., Hettich, Robert L., Serrani-Yarce, Juan C., Shrestha, Him K., Tschaplinski, Timothy J.   +7 more
core   +1 more source

Measuring catalytic mechanism similarity - a new approach to study enzyme function and evolution. [PDF]

FEBS J
We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Ribeiro AJM, Riziotis IG, Borkakoti N, Fernandes PA, Ramos MJ, Thornton JM.   +5 more
europepmc   +2 more sources

Quantitative Proteomics of Enriched Esophageal and Gut Tissues from the Human Blood Fluke Schistosoma mansoni Pinpoints Secreted Proteins for Vaccine Development [PDF]

, 2020
Schistosomes are blood-dwelling helminth parasites that cause schistosomiasis, a debilitating disease resulting in inflammation and, in extreme cases, multiple organ damage.
Beynon, Robert J, Brownridge, Philip, Castro-Borges, William, DeMarco, Ricardo, Eyers, Claire E, Harman, Victoria M, Holman, Stephen W, Neves, Leandro X, Wilson, R Alan   +8 more
core   +1 more source

Genome‐wide association study identifies five new cadmium uptake loci in wheat

The Plant Genome, Volume 13, Issue 2, July 2020., 2020
Abstract Cadmium (Cd) toxicity is a serious threat to future food security and health safety. To identify genetic factors contributing to Cd uptake in wheat, we conducted a genome‐wide association study with genotyping from 90K SNP array. A spring wheat diversity panel was planted under normal conditions and Cd stress (50 mg Cd/kg soil).
Luqman Bin Safdar, Fakhrah Almas, Sidra Sarfraz, Muhammad Ejaz, Zeshan Ali, Zahid Mahmood, Li Yang, Muhammad Massub Tehseen, Muhammad Ikram, Shengyi Liu, Umar Masood Quraishi   +10 more
wiley   +1 more source

Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes : implications for classification of enzyme function [PDF]

, 2010
The authors thank the National Institutes of Health (NIH R01 GM60595 to PCB) and the Scottish Universities Life Sciences Alliance (SULSA to JBOM) for funding.Functionally analogous enzymes are those that catalyze similar reactions on similar substrates ...
Daniel E. Almonacid, Emmanuel R. Yera, John B. O. Mitchell, Patricia C. Babbitt, Christine A. Orengo, RA George, JA Gerlt, PC Babbitt, JA Gerlt, ME Glasner, GJ Bartlett, MY Galperin, H Hegyi, ACR Martin, PF Gherardini, AE Todd, AE Todd, Z Zhang, S Tsoka, SA Teichmann, TD Otto, NH Horowitz, RA Jensen, GA Petsko, RA Chiang, CS Wright, BW Matthews, SC Morris, N Nagano, CT Porter, C Andreini, C Andreini, GL Holliday, GL Holliday, SC-H Pegg, SC-H Pegg, N Nagano, AG Murzin, G Ausiello, H Berman, NM O'Boyle, P Jaccard, P Willett, TF Smith, CA Orengo, AG McDonald, ACR Martin, SB Needleman, M Kotera, Y Yamanishi, GL Holliday, L Maveyraud, J Pitarch, R Castillo, JC Hermann, Z Wang, AP Leech, DG Gourley, AW Roszak, LM Blomberg, A Matte, MM Benning, PC Babbitt, DL Scott, BW Segelke, YS Ho, YS Ho, ME Lowe, Y Bourne, RJ Kazlauskas, H van Tilbeurgh, GJ Bartlett, T Nakai, A Zajc, E Ortlund, AB Hickman, TJ Wyckoff, CR Sweet, W Plaga, V Leppänen, F Himo, M Mathieu, Y Modis, RF Doolittle, V Sangar, BE Shakhnovich, PW Lord, J Gasteiger, O Sacher, DARS Latino, DARS Latino, DARS Latino, Y Loewenstein, T Dandekar, R Overbeek, AJ Enright, EM Marcotte, M Pellegrini, JC Hermann, JC Hermann, ME Glasner, L Jiang, M Bashton, K Tipton, KA Olszewski, R Preißner, J Park, PR Mittl, S Lorenzen, A Fersht, M Errami, EO Cannon, M Rizzi, J Symersky, Y Devedjiev, AR Battersby, N Frankenberg, MA Mathews, HL Schubert, B Stec, L Ma, JE Murphy, EB Fauman, RH Hoff, F Wang   +124 more
core   +3 more sources

Variations in marine microbiomes: from habitat to host [PDF]

, 2022
Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution September 2022.Microorganisms are the dominant life form on Earth and ...
Ma, Lei
core   +1 more source

Synthesis of novel bioactive lactose-derived oligosaccharides by microbial glycoside hydrolases [PDF]

, 2014
This is an open access article under the terms of the Creative Commons Attribution License.Prebiotic oligosaccharides are increasingly demanded within the Food Science domain because of the interesting healthy properties that these compounds may induce ...
Díez-Municio, Marina, Herrero, Miguel, Herrero, Miguel, Herrero, Miguel, Olano, Agustín, Moreno, F. Javier   +5 more
core   +1 more source

Correlation Of Fut2 And Fut3 Gene Polymorphisms With Inflammatory Bowel Disease In Guangxi Zhuang Population. [PDF]

Int J Gen Med
Xiaodan Lv,1,* Zhou Huang,2,* Shiquan Li,3 Xiaofang Xu,3 Deyi Chen,3 Lichun Han,3 Yu He,1 Shan Huang,1 Huiling Wu,1 Yunwei Qi,1 Liqiang Wei,1 Min Chen,1 Lingling Zhan,1 Xiaoping Lv3 1Department of Clinical Laboratory, the First Affiliated ...
Lv X, Huang Z, Li S, Xu X, Chen D, Han L, He Y, Huang S, Wu H, Qi Y, Wei L, Chen M, Zhan L, Lv X.   +13 more
europepmc   +3 more sources

Dissection of Hexosyl- and Sialyltransferase Domains in the Bifunctional Capsule Polymerases from Neisseria meningitidis W and Y Defines a New Sialyltransferase Family*

Journal of Biological Chemistry, 2014
Background: Capsule polymerases of Neisseria meningitidis serogroups W and Y comprise hexosyl- and sialyltransferase activity. Results: Hexosyltransferase activity is encoded by the predicted N-terminal GT-B fold.
A. Romanow, T. Keys, Katharina Stummeyer, Friedrich Freiberger, B. Henrissat, R. Gerardy-Schahn   +5 more
semanticscholar   +1 more source