Results 51 to 60 of about 4,356 (162)

Precision Cardiology: Phenotype-targeted Therapies for HFmrEF and HFpEF

International Journal of Heart Failure
Heart failure with mid-range ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) represent over half of heart failure cases but lack proven effective therapies beyond sodium-glucose cotransporter 2 inhibitor and diuretics. HFmrEF and HFpEF are heterogeneous conditions requiring precision phenotyping to enable tailored therapies.
Giuseppe M.C. Rosano, Cristiana Vitale, Ilaria Spoletini   +2 more
openaire   +2 more sources

Cardiac surveillance in immune checkpoint inhibitor therapy: Insights from the Essen Cardio‐oncology Registry

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia, Lisa Zimmer, Lena Lampe, Dimitra Vlachopoulou, Matthias Totzeck, Tienush Rassaf, Raluca I. Mincu   +6 more
wiley   +1 more source

Mineralocorticoid receptor antagonists: Efficacy and safety in chronic kidney disease

Diabetes, Obesity and Metabolism, EarlyView.
Abstract The mineralocorticoid receptor (MR) has a multifaceted role in normal physiologic functions. However, research has uncovered the deleterious consequences of overactivation of the MR. It has been implicated in chronic kidney disease (CKD) via its strong association with glomerulosclerosis, interstitial fibrosis, proteinuria, and decline in ...
Amy K. Mottl, Kamlesh Khunti, Chantal Mathieu   +2 more
wiley   +1 more source

Impact of diastolic dysfunction on outcome in heart failure patients with mid‐range or reduced ejection fraction

ESC Heart Failure, 2021
Aims The role of diastolic dysfunction (DD) in prognostic evaluation in heart failure (HF) patients with impaired systolic function remains unclear.
Dan Liu, Kai Hu, Kolja Lau, Tobias Kiwitz, Katharina Robitzkat, Clara Hammel, Björn Daniel Lengenfelder, Georg Ertl, Stefan Frantz, Peter Nordbeck   +9 more
doaj   +1 more source

The urinary albumin‐to‐creatinine ratio can direct personalized prevention and treatment for cardiovascular and chronic kidney disease

Journal of Internal Medicine, Volume 299, Issue 4, Page 444-466, April 2026.
Abstract Increased urinary albumin excretion is a strong predictor for cardiovascular events in persons with and without decreased glomerular filtration rate and can be assessed with the urinary albumin‐to‐creatinine ratio (UACR), which is a selective, sensitive, and convenient method for patients.
Holly J. Kramer, George L. Bakris
wiley   +1 more source

Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction

Singapore Medical Journal
Introduction: Data on heart failure (HF) with mildly reduced ejection fraction (HFmrEF) is still emerging, especially in Asian populations. This study aims to compare the clinical characteristics and outcomes of Asian HFmrEF patients with those of HF ...
Julian Cheong Kiat Tay, Shaw Yang Chia, Siew Hui Michelle Koh, David Kheng Leng Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Shao Guang Lee, Patrick Zhan Yun Lim, Jonathan Yap   +9 more
doaj   +1 more source

Association of ambient temperature and acute heart failure with preserved and reduced ejection fraction

ESC Heart Failure, 2022
Aims Evidence on the association between ambient temperature and the onset of acute heart failure (AHF) is scarce and mixed. We sought to investigate the incidence of AHF admissions based on ambient temperature change, with particular interest in ...
Takahiro Jimba, Shun Kohsaka, Masao Yamasaki, Toshiaki Otsuka, Kazumasa Harada, Yasuyuki Shiraishi, Shinji Koba, Makoto Takei, Takashi Kohno, Kenichi Matsushita, Tetsuro Miyazaki, Satoshi Kodera, Shigeto Tsukamoto, Kiyoshi Iida, Akito Shindo, Daisuke Kitano, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama, Tokyo CCU Network Scientific Committee   +19 more
doaj   +1 more source

Mortality and Morbidity in HFrEF, HFmrEF, and HFpEF Patients with Diabetes in the Middle East

Oman Medical Journal, 2020
We sought to estimate the mortality and morbidity in diabetic acute heart failure (AHF) patients stratified by left ventricular ejection fraction.We analyzed the data of patients with AHF from seven Middle Eastern countries (Bahrain, Oman, Yemen, Kuwait, UAE, Qatar, and Saudi Arabia) from February to November 2012, who were enrolled in a multinational ...
Mohammed Al-Jarallah, Rajesh Rajan, Ibrahim Al-Zakwani, Raja Dashti, Bassam Bulbanat, Mustafa Ridha, Kadhim Sulaiman, Alawi A. Alsheikh-Ali, Prashanth Panduranga, Khalid F. AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Nooshin Bazargani, Nidal Asaad, Haitham Amin   +17 more
openaire   +3 more sources

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

Phenotypes and Clinical Outcome of Heart Failure With Preserved Ejection Fraction Patients in China: Findings From the Chinese Cardiovascular Association Database‐Heart Failure Center Registry

MedComm, Volume 7, Issue 3, March 2026.
Structured graphical abstract‐text element Key Question It remains unclear whether patients with heart failure with preserved ejection fraction (HFpEF) in different phenotypes also have various clinical outcomes. Key Finding Significant differences existed in baseline characteristics and outcomes among different phenotypes; patients with HFpEF‐3 (right
Shuai Yuan, Zhonglei Xie, Xiaotong Cui, Shun Yao, Yamei Xu, Yanyan Wang, Yu Song, Kai Hu, Yugang Dong, Yuhua Liao, Weimin Li, Xinli Li, Jiefu Yang, Jingmin Zhou, Junbo Ge   +14 more
wiley   +1 more source