Results 141 to 150 of about 30,754 (261)

Aging and HFpEF: Are we running out of time?

Journal of Molecular and Cellular Cardiology, 2022
Withaar, Coenraad, Li, Sunhuo, Meems, Laura M.G., Silljé, Herman H.W., de Boer, Rudolf A.   +4 more
openaire   +3 more sources

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Abstract Mo104: Cardiolipin-Metabolite Crosstalk in HFpEF

only Background: Transition from fatty acid oxidation to glycolysis is linked to oncometabolism and cardiac hypertrophy. We hypothesize that such a metabolic shift is pivotal in driving HFpEF in 3 murine models.
Cowart, Lauren, Williams, Monique, Lopaschuk, Gary, Hare, Joshua, Kanashiro-Takeuchi, Rosemeire, Alborghetti, Marcos, Webster, Keith, Kamiar, Ali, Shinzato, Mariane, Kovilakath, Anna, Condor, Jose Manuel, Robleto, Emely, Cardoso, Alisson, Franchini, Kleber, Shehadeh, Lina, de Carvalho Pereira, Jose Geraldo, Takeuchi, Lauro   +16 more
core   +1 more source

HFpEF

JACC: Heart Failure, 2018
openaire   +1 more source

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

The Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert, Judith Hüttemeister, Paulina Sander, Nagaiah Chamakuri, Felix Hohendanner, Martin Falcke, Frank R. Heinzel   +6 more
wiley   +1 more source

CPET Characteristics in HFrEF, HFpEF and COPD

Chronic obstructive pulmonary disease (COPD) frequently occurs alongside heart failure (HF), including heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), creating a diagnostic dilemma due to ...
Guimei Wang, Xiaohong Wu, Yuqing Zhou
core   +1 more source

Gut Microbiota in Heart Failure with Preserved Ejection Fraction: Clinical Phenotyping and Therapeutic Opportunities. [PDF]

Biomedicines
Loncar G, Bojic M, Repac J, Cvetinovic N, Rakic M, Nedeljkovic T, Lunic T, Obradovic D, von Haehling S, Lainscak M, Otasevic P, Petrovic M, Blagojevic N, Vukasinovic D, Bozic B, Bozic Nedeljkovic B.   +15 more
europepmc   +1 more source

Cardiometabolic HFpEF: NASH of the Heart

Circulation, 2023
Capone, Federico, Vettor, Roberto, Schiattarella, Gabriele G   +2 more
openaire   +4 more sources

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Identification and reporting of heart failure with preserved ejection fraction in Sub-Saharan Africa: a scoping review of diagnostic approaches, echocardiographic assessment, and evidence gaps. [PDF]

Egypt Heart J
Adejumo FA, Olaniyan SG, Adejumo TP, Odunaro SK, Oba HA, Falope BJ, Kasali OE, Obielodan OO, Aderinto N.   +8 more
europepmc   +1 more source