Results 181 to 190 of about 36,198 (299)

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Patient‐Specific Lumped‐Parameter Model for Quantifying Vessel‐Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Personalized, patient‐specific biophysical model enabling mechanistic assessment of right ventricular (RV) function as well as robust differentiation of pulmonary hypertension (PH) subtype from routine clinical measurements of pulmonary arterial pressure and flow.
Christopher G. Lechuga, Amirreza Kachabi, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza, Naomi C. Chesler   +5 more
wiley   +1 more source

Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Dyslipidaemia is among the major risk factors for atherosclerotic cardiovascular disease. Paradoxically, higher cholesterol levels are associated with better survival in heart failure (HF) of any aetiology. Because cholesterol is an integral component of skeletal muscle structure, one possible explanation involves the interplay ...
Ryosuke Sato, Tania Garfias‐Veitl, Guglielmo Fibbi, Mirela Vatic, Wolfram Doehner, Stefan D. Anker, Stephan von Haehling   +6 more
wiley   +1 more source

Targeting Atrial Fibrillation in HFpEF: Comparative Effectiveness of Rhythm Control Strategies and Modulatory Effects of SGLT2 Inhibitors [PDF]

Marius-Dragoș Mihăilă, Ioan‐Alexandru Minciună, Bogdan Caloian, Florina Frîngu, Samuel Bogdan Todor, A. Aleman, Dana Pop   +6 more
openalex   +1 more source

P5656Heart failure with preserved ejection fraction (HFpEF) infrequently evolves towards a HFpEF-declined phenotype [PDF]

, 2018
Marta de Antonio, J Lupon, Giovana Gavidia‐Bovadilla, Jorge López‐Ayerbe, Pedro Moliner, Mar Domingo, Elena Ferrer, Aravinda Perera, Jose I. Nunez, Elisabet Zamora, Núria Vallejo, Francisco Gual, Albert Teis, Gladys Juncà, Antoni Bayés‐Genís   +14 more
openalex   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

The Farm to Table HFpEF Kitchen

Amrut V. Ambardekar, Benjamin J. Kopecky
openalex   +1 more source

Focus on HFpEF in heart failure

Chinese Medical Journal, 2022
Chunhui He, Rongchong Huang, Ningning Wang   +2 more
openaire   +3 more sources

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 878-894, February 2026.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck, Charnkamal Singh Bhogal, Markus Mandl   +2 more
wiley   +1 more source

Mitochondrial Targeting by Elamipretide Improves Myocardial Bioenergetics Without Translating into Functional Benefits in HFpEF. [PDF]

Int J Mol Sci
Schauer A, Jahn D, Vahle B, Barthel P, Männel A, Fabig G, Linke A, Adams V, Augstein A.   +8 more
europepmc   +1 more source