Results 181 to 190 of about 6,261 (210)

Molecular recognition and structural plasticity in amyloid-nucleic acid complexes. [PDF]

J Struct Biol
Kukreja R, Latham MP.
europepmc   +1 more source

An Hfq-binding sRNA in Listeria monocytogenes regulates a virulence adhesin in an Hfq-independent manner

, 2012
Sievers, Susanne, Jacobsen, Kirstine, Lillebæk, Eva Maria Sternkopf, Nielsen, Pia Kiil, Lund, Anja, Kallipolitis, Birgitte H.   +5 more
openaire   +1 more source

Acoziborole resistance associated mutations in trypanosome CPSF3

Ridgway M, Novotna M, Mendoza-Martinez C, Tinti M, Altmann S, Sloan G, Horn D.   +6 more
europepmc   +1 more source

Condensation of the RNA chaperone Hfq is coupled to inhibition of carbon assimilation and contributes to the stabilisation of regulatory RNAs in nitrogen starved Escherichia coli

McQuail J, Ellis H, Behrends V, Balcells-Nadal C, Bischler T, Gräfenhan T, Wigneshweraraj S.   +6 more
europepmc   +1 more source

Hfq and its constellation of RNA [PDF]

Nature Reviews Microbiology, 2011
Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has key roles in the control of gene expression. By facilitating the pairing of small RNAs with their target mRNAs, Hfq affects the translation and turnover rates of specific transcripts and contributes to complex post-transcriptional networks.
Jörg Vogel, Ben F Luisi, Vogel Jörg
exaly   +3 more sources

Characterization of Vibrio cholerae Hfq Provides Novel Insights into the Role of the Hfq C-Terminal Region

Journal of Molecular Biology, 2012
Hfq is a bacterial RNA binding protein that facilitates small RNA-mediated posttranscriptional gene regulation. In Vibrio cholerae, Hfq and four Hfq-dependent small RNAs are essential for the expression of virulence genes, but little is known about this mechanism at the molecular level. To better understand V.
Helen A Vincent, Acely Garza-García, Marc Malfois   +2 more
exaly   +5 more sources

Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein [PDF]

EMBO Journal, 2002
In prokaryotes, Hfq regulates translation by modulating the structure of numerous RNA molecules by binding preferentially to A/U-rich sequences. To elucidate the mechanisms of target recognition and translation regulation by Hfq, we determined the crystal structures of the Staphylococcus aureus Hfq and an Hfq-RNA complex to 1.55 and 2.71 A resolution ...
Maria A Schumacher, Thorleif Møller, Poul Valentin-Hansen   +2 more
exaly   +4 more sources

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The role of Hfq in bacterial pathogens

Current Opinion in Microbiology, 2010
The ubiquitous RNA-binding protein, Hfq, has been shown to be required for the fitness and virulence of an increasing number of bacterial pathogens. Mutants lacking Hfq are often sensitive to host defense mechanisms and highly attenuated in animal models, albeit there is considerable variation in both severity and extent of phenotypes. RNomics and deep
Chao, Y., Vogel, J.
openaire   +3 more sources

Hfq structure, function and ligand binding

Current Opinion in Microbiology, 2007
Recent studies on Hfq have provided a deeper understanding of the multiple functions of this pleiotropic post-transcriptional regulator. Insights into the mechanism of Hfq action have come from a variety of approaches. A key finding was the characterization of two RNA binding sites: the Proximal Site, which binds sRNA and mRNA; and the Distal Site ...
Richard G, Brennan, Todd M, Link
openaire   +2 more sources

Structure ofPseudomonas aeruginosaHfq protein

Acta Crystallographica Section D Biological Crystallography, 2005
The structure of the Hfq protein from Pseudomonas aeruginosa was determined using two different ionic conditions. In both cases the molecules formed identical hexameric rings, but some variations in the crystal packing were revealed. Hfq belongs to the family of Sm/LSm proteins, the members of which can form hexameric as well as heptameric rings ...
Nikulin, Alexey D., Stolboushkina, Elena, Perederina, Anna, Vassilieva, Ioulia M., Bläsi, Udo, Moll, Isabella, Kachalova, Galina, Yokoyama, Shigeyuki, Vassylyev, Dmitry, Garber, Maria B., Nikonov, Stanislav   +10 more
openaire   +3 more sources