Results 91 to 100 of about 13,098 (176)

Genome-Wide Survey of MicroRNA - Transcription Factor Feed-Forward Regulatory Circuits in Human

, 2009
In this work, we describe a computational framework for the genome-wide identification and characterization of mixed transcriptional/post-transcriptional regulatory circuits in humans. We concentrated in particular on feed-forward loops (FFL), in which a
Alvarez-Garcia, Angela Re, Calin, Chan, Chen, Corà, Corà, Corà, Daniela Taverna, Davide Corá, Elnitski, Esquela-Kerscher, Filipowicz, Gershengom, Griffiths-Jones, Gudmundsson, He, Hornstein, Hubbard, Iorio, Joglekar, John, Konagurthu, Krek, Ladd, Lai, Landgraf, Lee, Lewis, Lewis, Liu, Loots, Martinez, Matys, Mazurie, Michele Caselle, Milo, Nielsen, O’Donnell, Pan, Pesole, Phan, Saini, Shalgi, Shen-Orr, Tsang, Wagner, Wilkerson, Xie, Zeller, Zhang, Zhao   +51 more
core   +1 more source

StemCellNet: an interactive platform for network-oriented investigations in stem cell biology. [PDF]

, 2014
Stem cells are characterized by their potential for self-renewal and their capacity to differentiate into mature cells. These two key features emerge through the interplay of various factors within complex molecular networks.
Assou, Balic, Becker, Ben-Porath, Blake, Boyer, Chatr-Aryamontri, Chen, Chia, Ding, Eppert, Fortunel, Gaspar, Glinsky, Gray, Hansson, Hou, Hu, Ivanova, Joana M. Xavier, José Bragança, José P. Pinto, Jung, Kalathur, Kalathur, Koeva, Lopes, Matthias E. Futschik, Mudunuri, Obokata, Palmer, Ramalho-Santos, Ravi Kiran Reddy Kalathur, Reya, Rui S. R. Machado, Seita, Takahashi, Wang, Wang, Xu, Yu   +40 more
core   +3 more sources

Why digital medicine depends on interoperability [PDF]

, 2019
Digital data are anticipated to transform medicine. However, most of today's medical data lack interoperability: hidden in isolated databases, incompatible systems and proprietary software, the data are difficult to exchange, analyze, and interpret. This
Essenwanger, Andrea, Lehne, Moritz, Sass, Julian, Schepers, Josef, Thun, Sylvia   +4 more
core   +1 more source

Dynamic Regulation of Collagens, Proteases, Their Inhibitors, and Cell Death in Experimental Asthma in Mice

Allergy, Volume 81, Issue 1, Page 170-184, January 2026.
This study investigates airway remodeling in acute and chronic experimental asthma models induced by house dust mite extract to elucidate inflammatory and structural changes. Two acute T2‐low models demonstrated pronounced airway inflammation characterized by goblet cell hyperplasia, collagen deposition, and significant upregulation of extracellular ...
Marlena Tynecka, Agnieszka Tarasik, Bartosz Hanczaruk, Adrian Janucik, Krystian Czolpinski, Alicja Walewska, Arkadiusz Zbikowski, Anna Zeller, Agnieszka Kulczynska‐Przybik, Magdalena Niemira, Joanna Reszec‐Gielazyn, Barbara Mroczko, Adam Kretowski, Cezmi A. Akdis, Milena Sokolowska, Marcin Moniuszko, Cagatay Karaaslan, Andrzej Eljaszewicz   +17 more
wiley   +1 more source

Recommendations for future extensions to the HGNC gene fusion nomenclature [PDF]

Leukemia, 2021
Alex H. Wagner, Yassmine Akkari, Marilyn Li, Angshumoy Roy, Karen Tsuchiya, Gordana Raca   +5 more
openaire   +2 more sources

HGNC: promoting standardized gene names for 40 years

, 2019
The HUGO Gene Nomenclature Committee (HGNC, www.genenames.org), working closely with authors, journals, annotating groups and other nomenclature committees, has been responsible for assigning approved human gene names for the last 40 years. While unique IDs are undoubtedly the most unambiguous way to identify genes, they are not practical for many ...
Tweedie, Susan, Seal, Ruth, Braschi, Bryony, Denny, Paul, Gray, Kristian, Jones, Tamsin, Yates, Beth, Bruford, Elspeth   +7 more
openaire   +1 more source

Taxonomic Deception via Obvious Traits: Oversplitting in European Vallonia Risso, 1826 (Mollusca: Gastropoda: Valloniidae)

Zoologica Scripta, Volume 55, Issue 1, Page 37-51, January 2026.
ABSTRACT The status of the six traditionally recognised European Vallonia taxa is considered based on mtDNA and nDNA sequences from five independently sorting loci in combination with morphometric landmark analyses conducted on genetically confirmed shells. These analyses document that only two species are valid (V. costata and V.
Jeffrey C. Nekola, Jochen Gerber, Veronika Horsáková, Eva Líznarová, Sara Kafimola, Eva Mikulášková, Markéta Nováková, Michal Horsák   +7 more
wiley   +1 more source

Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes

Cell Reports, 2012
The ubiquitin-proteasome system is essential for maintaining protein homeostasis. However, proteasome dysregulation in chronic diseases is poorly understood.
Sang Mi Shim, Won Jae Lee, Youngdoo Kim, Jong Wook Chang, Sungmin Song, Yong-Keun Jung   +5 more
doaj   +1 more source

Gene variants of unknown significance in Fabry disease: Clinical characteristics of c.376A>G (p.Ser126Gly)

Molecular Genetics & Genomic Medicine, 2022
Background Anderson–Fabry disease (FD) is an X‐linked lysosomal storage disorder with varying organ involvement and symptoms, depending on the underlying mutation in the alpha‐galactosidase A gene (HGNC: GLA).
Kolja Lau, Nurcan Üçeyler, Tereza Cairns, Lora Lorenz, Claudia Sommer, Magnus Schindehütte, Kerstin Amann, Christoph Wanner, Peter Nordbeck   +8 more
doaj   +1 more source

HAGR: the Human Ageing Genomic Resources [PDF]

, 2004
The Human Ageing Genomic Resources (HAGR) is a collection of online resources for studying the biology of human ageing. HAGR features two main databases: GenAge and AnAge. GenAge is a curated database of genes related to human ageing.
Costa, Joana, de Magalhães, João Pedro, Toussaint, Olivier   +2 more
core   +2 more sources