Results 191 to 200 of about 78,665,240 (283)

H‐Bonding‐Induced Repulsion Between Small Groups Toward a Highly Puckered Benzene

Advanced Science, EarlyView.
A benzene derivative bearing methylamino and nitro substituents adopts a boat‐shaped ring conformation. Comparison with four related compounds supports a role for intramolecular hydrogen bonding in constraining substituent orientations and promoting local steric crowding associated with ring puckering.
Chaofeng Zhao, Qi Sun, Ning Ding, Xiaoting Ren, Jinxuan He, Shenghua Li, Siping Pang   +6 more
wiley   +1 more source

Mast Cell-Microglia Crosstalk Drives Aberrant Synaptic Pruning Through PAR-2/MAPK/NF-κB Signaling in Neonatal Hypoxic-Ischemic Encephalopathy. [PDF]

CNS Neurosci Ther
Yang Y, Cai D, Yu J, Zhu Y, Huang Y, Lin Y, Teng C, Wei J, Lin Y, Dai D, Xue F, Chen A, Zheng X, Chen X.   +13 more
europepmc   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

A phase 1b/2 study of ceralasertib, a selective inhibitor of ATR, in patients with relapsed or refractory MDS and CMML. [PDF]

Blood Adv
Brunner AM, Liu Y, Garcia JS, Mendez L, Gutierrez Moore C, Srivatsan SN, Shao J, Aubrey BJ, Amrein P, Narayan R, Vedula R, Friedman E, Neuberg D, Andrade-Campos M, Smith SA, Stone R, Fathi AT, Walter MJ, Graubert TA, Jacoby MA.   +19 more
europepmc   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

NLRP3 Regulation in Neonatal Hypoxic-Ischemic Encephalopathy-Focus on Microglial Activation. [PDF]

Int J Mol Sci
Burkard H, Bernis ME, Bremer AS, Maes E, Walter J, Meissner F, Sabir H.   +6 more
europepmc   +1 more source

3′‐UTR Hypermethylation and ABA Signaling Coordinate Transcriptional Activation of SWEET14 for High Sugar Accumulation in Citrus

Advanced Science, EarlyView.
Hypermethylation of CliSWEET14 3′‐UTR relieves ClibHLH105‐mediated transcriptional repression, together with ABA signaling‐mediated activation of the CliABF3‐CliNAC56 cascade, boosts CliSWEET14 expression and sucrose accumulation in citrus. ABSTRACT Sugar accumulation is pivotal for fruit quality, yet the molecular regulation of this process remains ...
Yike Zeng, Yue Wang, Yilei Wang, Haowei Chen, Qiyu Chen, Wei Xiao, Aoqing Zhang, Xin Jiang, Xiangming Shang, Zhicheng Yang, Xi Zeng, Wenqiang Hu, Chunlong Li, Ji‐Hong Liu   +13 more
wiley   +1 more source

Reductions in chronic pain cognitions and impact following intensive trauma and pain rehabilitation treatments: A case study. [PDF]

Psychol Trauma
Miller ML, Flegge LG, Wasson RS, Williams AE, Wakefield AE, Henderson DR, Bushey MA.   +6 more
europepmc   +1 more source

Effects of Fetal Bovine Serum on Biofilm Formation and Cell Attachment of <i>Candida glabrata</i>. [PDF]

Microorganisms
Vecci BE, Deshpande SN, Baudin J, Kao KC.   +3 more
europepmc   +1 more source

A Mechanistic Dissection of Multifaceted Complement Attack in Age‐Related Macular Degeneration Reveals the Superiority of C3 Inhibition

Advanced Science, EarlyView.
Complement‐mediated RPE degeneration extends beyond terminal MAC injury. A four‐hit mechanism emerges in which C3a and C5a disrupt mitochondrial function, while C3b and MAC compromise the phagolysosomal system. Upstream C3 inhibition suppresses this full spectrum of pathogenic effectors, providing broader cellular protection than C5 blockade.
Zhidong Chen, Mingshuang Wang, Huiqin Liu, Feng Qian   +3 more
wiley   +1 more source