Results 181 to 190 of about 41,584,039 (265)

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Rhizodeposition Drives One Third of Belowground Carbon Input in Agroecosystems

Advanced Science, EarlyView.
This study quantifies photosynthesized C allocation in the plant–soil system across six crop types: barley, wheat, maize, rice, legumes and grasses. It reports C partitioning into shoot respiration, shoot‐C, root‐C, net rhizodeposition and root‐derived CO2, providing standardized percentage averages and GPP‐derived absolute values as a robust baseline ...
Zhengjun Yan, Yuan Wen, Jie Zhou, Yakov Kuzyakov, Damien Beillouin, Johannes Lehmann, Yadong Yang, Yiqi Luo, Pete Smith, Zhaohai Zeng, Huadong Zang   +10 more
wiley   +1 more source

Deciphering the 3D genome organization across species from Hi-C data. [PDF]

Nucleic Acids Res
Shkolikov A, Galitsyna A, Gelfand MS.
europepmc   +1 more source

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

SHICEDO: single-cell Hi-C data enhancement with reduced over-smoothing. [PDF]

Bioinformatics
Huang J, Ma R, Strobel M, Hu Y, Ye T, Jiang T, Ma W.   +6 more
europepmc   +1 more source

Freestanding PZT Films for Integrated Wearable Sensing and Intelligent Acoustic Recognition

Advanced Science, EarlyView.
A freestanding epitaxial PZT/LaNiO3/Pt heterostructure is achieved via water‐assisted delamination from mica, effectively eliminating substrate‐induced clamping and releasing intrinsic ferroelectricity. The released film exhibits substantially enhanced remanent polarization and piezoelectric response, delivering excellent mechanical flexibility and ...
Hailong Pan, Zhichao Xu, Rongxiao Liu, Jianmei Pei, Changhong Yang, Shifeng Huang, Michael Wübbenhorst   +6 more
wiley   +1 more source

Hardware Acceleration of Stochastic Neural Networks Enabled by Bit‐Cell Level Co‐Design of Magnetic Tunnel Junctions

Advanced Science, EarlyView.
An MTJ‐based probabilistic processing‐in‐memory architecture unites nonvolatile storage, local entropy generation, and stochastic computation within each memory cell. Stored multi‐bit weights are converted directly into programmable stochastic bitstreams, enabling neural‐network inference, adaptive Ising optimization, and uncertainty‐aware Bayesian ...
Qiuyuan Wang, Dooyong Koh, Brooke McGoldrick, Tudor Mocioi, Yabin Fan, Marc Baldo, Luqiao Liu   +6 more
wiley   +1 more source

szKendall: spatial-structural-zero-aware dissimilarity measures for subtype discovery using single cell Hi-C data. [PDF]

Nat Commun
Liu Y, Lee SW, Kim T, Jin V, Lin S.
europepmc   +1 more source

Balancing Shading and Resistive Losses: 33% Efficient Perovskite/Silicon Tandem Solar Cells via Front‐Electrode Engineering

Advanced Science, EarlyView.
Front‐electrode co‐optimization combining tungsten‐doped indium oxide (IWO) transparent electrode and simulation‐guided metal grid geometry boosts perovskite/silicon tandem solar cell performance. The low work function IWO improves interfacial carrier extraction, while tailored grid parameters balance optical shading and electrical resistive losses ...
Yuhui Ji, Fei Wang, Junjun Li, Yunren Luo, Haichuan Zhang, Qi Liu, Pengxu Chen, Kexin Yao, Qiang Shi, Fanying Meng, Liping Zhang, Chen Yang, Jiakai Liu, Zhengxin Liu, Wenzhu Liu, Jian Yu   +15 more
wiley   +1 more source

Integrating Hi-C data and RNA-seq data to reveal the 3D genome in sheep. [PDF]

BMC Genomics
Xu Q, Zhang X, Li F, Tian H, Zhang D, Huang K, Zhang Y, Zhao Y, Li X, Zhao L, Cheng J, Xu D, Ma Z, Yang X, Weng X, Wang W.   +15 more
europepmc   +1 more source