Results 201 to 210 of about 41,584,039 (265)

H‐Bonding‐Induced Repulsion Between Small Groups Toward a Highly Puckered Benzene

Advanced Science, EarlyView.
A benzene derivative bearing methylamino and nitro substituents adopts a boat‐shaped ring conformation. Comparison with four related compounds supports a role for intramolecular hydrogen bonding in constraining substituent orientations and promoting local steric crowding associated with ring puckering.
Chaofeng Zhao, Qi Sun, Ning Ding, Xiaoting Ren, Jinxuan He, Shenghua Li, Siping Pang   +6 more
wiley   +1 more source

A comprehensive review and benchmark of differential analysis tools for Hi-C data. [PDF]

Brief Bioinform
Jorge E, Foissac S, Neuvial P, Zytnicki M, Vialaneix N.   +4 more
europepmc   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Synergistic Effects of Separator Architecture and Electrolyte Chemistry on the Electrochemical Stability of Lithium Ion Batteries With Li–Mn Rich Cathodes and µ‐Si Anodes

Advanced Science, EarlyView.
This work reveals that synergistic engineering of separator architecture and electrolyte chemistry determines the long‐term stability of LMR||µ‐Si cell chemistry. The introduction of N, N‐dimethylsulfamoyl fluoride (DMFSA) as a co‐solvent with fluoroethylene carbonate (FEC) promotes robust interphases on both electrodes, effectively mitigates side ...
Marian Cristian Stan, Bärbel Arling, Gerrit Michael Overhoff, Kirstin Darida, Lucas Marquart, Peng Yan, Lara Kersting, Linus Voigt, Laurin Profanter, Hyung‐Tae Kim, Martin Winter, Gunther Brunklaus, Isidora‐Cekic Laskovic   +12 more
wiley   +1 more source

PB-DiffHiC: a statistical framework for detecting differential chromatin interactions from high resolution pseudo-bulk Hi-C data. [PDF]

BMC Genomics
Zhou Y, Hu Y, Tan L, Zhu J, Fei Y, Gu M, Tian D.   +6 more
europepmc   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

The first high-quality chromosome-level genome of Parupeneus biaculeatus using HiFi and Hi-C data. [PDF]

Sci Data
Luo Z, Yi M, Yang X, Luo Z, Li X, Jiang C, Kang B, Huang L, Lin HD, He X, Yan Y.   +10 more
europepmc   +1 more source

3′‐UTR Hypermethylation and ABA Signaling Coordinate Transcriptional Activation of SWEET14 for High Sugar Accumulation in Citrus

Advanced Science, EarlyView.
Hypermethylation of CliSWEET14 3′‐UTR relieves ClibHLH105‐mediated transcriptional repression, together with ABA signaling‐mediated activation of the CliABF3‐CliNAC56 cascade, boosts CliSWEET14 expression and sucrose accumulation in citrus. ABSTRACT Sugar accumulation is pivotal for fruit quality, yet the molecular regulation of this process remains ...
Yike Zeng, Yue Wang, Yilei Wang, Haowei Chen, Qiyu Chen, Wei Xiao, Aoqing Zhang, Xin Jiang, Xiangming Shang, Zhicheng Yang, Xi Zeng, Wenqiang Hu, Chunlong Li, Ji‐Hong Liu   +13 more
wiley   +1 more source

STRIDE: A Sequencing Depth Robust Metric for Sparse Chromosome Conformation Capture Data Comparison

Advanced Science, EarlyView.
A mean first passage time (MFPT)‐based representation transforms sparse Hi‐C contact maps into robust topological representations, preserving biologically meaningful chromatin features and facilitating robust analysis of TADs, chromatin loops, differential chromatin contacts, and sparse single‐cell Hi‐C data.
Bingxiang Xu, Xiaomeng Gao, Weichu Tao, Zhihua Zhang, Feifei Li   +4 more
wiley   +1 more source

Unicorn: enhancing single-cell Hi-C data with blind super-resolution for 3D genome structure reconstruction. [PDF]

Bioinformatics
Chandrashekar MKB, Menon R, Olowofila S, Oluwadare O.   +3 more
europepmc   +1 more source