Results 71 to 80 of about 41,584,039 (265)
Rich chromatin structure prediction from Hi-C data [PDF]
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2015 ABSTRACT Recent studies involving the 3-dimensional conformation of chromatin have revealed the important role it has to play in different processes within the cell. These studies have also led to the discovery of densely interacting segments of the chromosome, called topologically associating domains.
Laraib Malik, Rob Patro
openaire +3 more sources
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
GILoop: Robust chromatin loop calling across multiple sequencing depths on Hi-C data
iScience, 2022 Summary: Graph and image are two common representations of Hi-C cis-contact maps. Existing computational tools have only adopted Hi-C data modeled as unitary data structures but neglected the potential advantages of synergizing the information of ...
Fuzhou Wang +7 more
doaj +1 more source
Loop detection using Hi-C data with HiCExplorer
, 2021 Results files of the data described in 'Loop detection using Hi-C data with ...
Joachim Wolff
core +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Hi-C maps, 3D communities, and domains.
, 2023 (a) Hi-C maps where the red-to-blue pixel colors are a proxy for short-to-long 3D distances. The squares decorating the map’s diagonals represent GenLouvain-derived 3D communities for three γ values (0.5, 0.6, and 0.7).
Dolores Bernenko (16528426) +3 more
core +1 more source
SnapHiC2: A computationally efficient loop caller for single cell Hi-C data
Computational and Structural Biotechnology Journal, 2022 Single cell Hi-C (scHi-C) technologies enable the study of chromatin spatial organization directly from complex tissues at single cell resolution.
Xiaoqi Li +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
, 2022 Dependencies AMReX: release 22.02 openPMD-api: release 0.14.3 What's Changed Include destructor of hipace in profiler by @AlexanderSinn in https://github.com/Hi-PACE/hipace/pull/639 Pass the number of ghost cells to amrex::MultiFab::setVal, etc.
Lehe, Remi +6 more
core +1 more source
Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora
FEBS Open Bio, EarlyView.This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi +6 more
wiley +1 more source