The potential role of the SIRT1‐Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress [PDF]
Cell Biology InternationalHidden hearing loss (HHL) is characterized by normal audiometric thresholds but impaired auditory function, particularly in noisy environments. In vivo, we employed auditory brainstem response (ABR) testing and ribbon synapses counting to assess changes ...
Tian Li
exaly +3 more sources
Animal-to-Human Translation Difficulties and Problems With Proposed Coding-in-Noise Deficits in Noise-Induced Synaptopathy and Hidden Hearing Loss [PDF]
Frontiers in Neuroscience, 2022 Noise induced synaptopathy (NIS) and hidden hearing loss (NIHHL) have been hot topic in hearing research since a massive synaptic loss was identified in CBA mice after a brief noise exposure that did not cause permanent threshold shift (PTS) in 2009 ...
Ripley S +4 more
exaly +3 more sources
Assessment of Hidden Hearing Loss in Tinnitus patients with Normal hearing
The Egyptian Journal of OtolaryngologyBackground Hidden hearing loss (HHL) is an auditory condition that impacts auditory neurological processing and hearing sensitivity in individuals with normal hearing.
Yomna Magdy Zoghba +3 more
doaj +3 more sources
Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects. [PDF]
PLoS Computational Biology, 2021 Hidden hearing loss (HHL) is an auditory neuropathy characterized by normal hearing thresholds but reduced amplitudes of the sound-evoked auditory nerve compound action potential (CAP).
Maral Budak +5 more
doaj +3 more sources
Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss [PDF]
Neural Plasticity, 2016 Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs ...
Lijuan Shi +5 more
doaj +5 more sources
Toward a Differential Diagnosis of Hidden Hearing Loss in Humans. [PDF]
PLoS ONE, 2016 Recent work suggests that hair cells are not the most vulnerable elements in the inner ear; rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate first in the aging or noise-exposed ear.
M Charles Liberman +4 more
doaj +7 more sources
Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms. [PDF]
Cold Spring Harb Perspect Med, 2020 Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to affect auditory neural processing and hearing acuity in subjects with normal audiometric thresholds, particularly in noisy environments.
C Kohrman D +3 more
europepmc +5 more sources
Primary Neural Degeneration in the Human Cochlea: Evidence for Hidden Hearing Loss in the Aging Ear [PDF]
Neuroscience, 2019 The noise-induced and age-related loss of synaptic connections between auditory-nerve fibers and cochlear hair cells is well-established from histopathology in several mammalian species; however, its prevalence in humans, as inferred from ...
V De Gruttola, M C Liberman
exaly +3 more sources
Consequences and Mechanisms of Noise-Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing. [PDF]
Adv Sci (Weinh)Noise‐induced synaptopathy and relevant hidden hearing loss (NIS and NIHHL) have been a hot topic in hearing research for almost 15 years. The progress is summarized in this review to address the reversibility of the synaptic damage after the initial ...
Wang H, Aiken SJ, Wang J.
europepmc +2 more sources
Involvement of the SIRT1/PGC-1α Signaling Pathway in Noise-Induced Hidden Hearing Loss. [PDF]
Front Physiol, 2022 Objective: To establish an animal model of noise-induced hidden hearing loss (NIHHL), evaluate the dynamic changes in cochlear ribbon synapses and cochlear hair cell morphology, and observe the involvement of the SIRT1/PGC-1α signaling pathway in NIHHL ...
Liu YH +7 more
europepmc +2 more sources