Results 61 to 70 of about 1,188,378 (292)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Hierarchical Control Strategy for the Cooperative Braking System of Electric Vehicle

open access: yesThe Scientific World Journal, 2015
This paper provides a hierarchical control strategy for cooperative braking system of an electric vehicle with separated driven axles. Two layers are defined: the top layer is used to optimize the braking stability based on two sliding mode control ...
Jiankun Peng   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

A method of optimizing the structure of hierarchical distributed control systems

open access: yesНаучно-технический вестник информационных технологий, механики и оптики
A description of the control system represented in the form of an oriented graph and a method for formalization of the problem of choosing a variant of the control system structure are proposed.
A. Yu. Onufrey   +2 more
doaj   +1 more source

Hierarchical Decomposition of Nonlinear Dynamics and Control for System Identification and Policy Distillation

open access: yes, 2020
The control of nonlinear dynamical systems remains a major challenge for autonomous agents. Current trends in reinforcement learning (RL) focus on complex representations of dynamics and policies, which have yielded impressive results in solving a ...
Abdulsamad, Hany, Peters, Jan
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

A multidisciplinary coupling relationship coordination algorithm using the hierarchical control methods of complex systems and its application in multidisciplinary design optimization

open access: yesAdvances in Mechanical Engineering, 2016
Because of the increasing complexity in engineering systems, multidisciplinary design optimization has attracted increasing attention. High computational expense and organizational complexity are two main challenges of multidisciplinary design ...
Rong Yuan, Haiqing Li
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Hierarchical Coupling/Disturbance-Utilization Control for Tiltable Quadrotors

open access: yesAerospace
Tiltable quadrotors have the ability of independent control of position and attitude, which can be more flexible in complex task scenarios. However, the inherent unmodeled dynamics, model uncertainties, and external disturbances pose significant ...
Tiancai Wu, Jie Bai, Min Xiong
doaj   +1 more source

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