Results 191 to 200 of about 84,588 (227)

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Molecular Mechanism of Dihydroquercetin in Ameliorating Metabolic Dysfunction-Associated Steatotic Liver Disease: Insights Into the HIF-1α/VEGF Pathway. [PDF]

Food Sci Nutr
Zhang X, Zhang H, Wu B, Wu P, Shen A, Zhang C, Zeng Y, Wang Y, Xu H, He Y, Wang L.   +10 more
europepmc   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Modulation of breast cancer progression in high-altitude hypoxia by Tongqiaohuoxue Decoction via HIF-1α/VEGF signaling. [PDF]

Discov Oncol
Yang W, Wang Q, Yang Q, Peng Y, Gao Y, Yang H, Lan W, Zhang T, Zhang S, Su Z, Zhao X, Ma X.   +11 more
europepmc   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Targeting Polyamine Metabolism in Colorectal Cancer: Apigenin Dismantles the HIF-1α/SMOX Positive Feedback Loop to Suppress Tumor Progression. [PDF]

Int J Mol Sci
Zhang Z, Xiang B, Geng R, Ji X, Wang D, Yin Z, Chen L, Liu J.   +7 more
europepmc   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Nanobubble-Mediated Oxygen Delivery Mitigates Hypoxia-Induced ROS and HIF-1α Expression in UC-MSCs. [PDF]

Nanomaterials (Basel)
Víafara-García SM, Torres G, Chacón C, Palma JL, Rojas-Nunez J, Landaeta E, Acevedo Cox JP.   +6 more
europepmc   +1 more source

Apigenin Protects H9c2 Cells Against Oxygen-Glucose Deprivation/Reperfusion Injury by Regulating Autophagy via the HIF-1α/miR-20a Axis. [PDF]

Pharmacol Res Perspect
Zhao X, Li H, Yuan Y, Cao Q, Yu B, Xue W, Yu G, Wang Y, Niu X, Wang Y.   +9 more
europepmc   +1 more source