Results 211 to 220 of about 136,040 (279)

The RASSF1C-HIF-1α axis drives macrophage lipid metabolism to promote pancreatic cancer. [PDF]

Cell Death Dis
Zhan T, Huang M, Chen M, Chen W, Wang Y, Chen X, Zou Y, Liu M, Zhu Q, Tian X, Han Z, Huang X.   +11 more
europepmc   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

ATRA improves megakaryopoiesis in immune thrombocytopenia through up-regulating the HIF-1α/SPHK2/S1P pathway. [PDF]

Sci Adv
Huang QS, Xue J, Liu FQ, Chen Q, Zhang G, Sun XY, Wang C, Yang L, Hou Y, Li Y, Wang Q, Peng J, Hou M, Zhao X, Kong Y, Chang Y, Zhao X, Huang XJ, Zhang XH.   +18 more
europepmc   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Rhaponticin alleviates pancreatic acinar cell necrosis by attenuating oxidative stress via modulation of the HIF-1α signaling pathway. [PDF]

Redox Rep
Xie X, Yang P, Wang S, Xu X, Wang L, Li P, Lu G, Chen W, Sun R, Zhang J, Wang Z.   +10 more
europepmc   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Treg cells protect astrocytes from ferroptosis after subarachnoid hemorrhage by activating the HIF-1α/Hmox1 pathway. [PDF]

Front Immunol
Huang L, Yao Z, Meng F, Liu Y, Li Y, Shi H.   +5 more
europepmc   +1 more source

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
MMP1 and TGFBR2 were validated by machine learning and external datasets as the candidate genes. Dexamethasone showed strong binding affinity to MMP1 (−7.72 kcal/mol) and TGFBR2 (−7.27 kcal/mol) in docking studies. Knockdown of MMP1 repressed the malignant phenotypes of NPC cells.
Feng Wang, Binbin Ge, Ming Li, Xiaochun Xia, Fuming Zhang, Pengqin Xu   +5 more
wiley   +1 more source

Emodin Attenuates Rheumatoid Arthritis by Modulating the NF-κB/HIF-1α/VEGF Signaling Pathway. [PDF]

Int J Mol Sci
Du D, Lou Y, Zhou L, Tian J, Zhang T, Qiu Z, Rong X.   +6 more
europepmc   +1 more source

Causal Interplay Between Inflammatory Cytokines and Lipid Metabolites in Serous Ovarian Carcinoma: Insights From a Genetic Association Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study utilizes a two‐sample Mendelian randomization framework to establish a causal link between circulating inflammatory proteins, blood metabolites, and the risk of serous ovarian carcinoma. Our findings identify Interleukin‐8 as a significant risk factor and demonstrate that 1‐Palmitoyl‐GPG (16:0) acts as a metabolic mediator within this ...
Chong‐ze Yang, Lan‐hui Qin, Cheng‐can Huang, Xiao‐li Huang, Ying‐xia Yang, Wei Lan, Miao Fan   +6 more
wiley   +1 more source